The pathophysiological roles and the therapeutic potentials of Myc family are reviewed in
this article. The physiological functions and molecular machineries in stem cells, including …

Retinoids are ubiquitous signaling molecules that influence nearly every cell type, exert
profound effects on development, and complement cancer chemotherapeutic regimens. All …

Purpose We assessed the long-term outcome of patients enrolled on CCG-3891, a high-risk
neuroblastoma study in which patients were randomly assigned to undergo autologous …

Our forefathers in pathology, on observing cancer tissue under the microscope in the mid-
19th century, noticed the similarity between embryonic tissue and cancer, and suggested …

Late‐onset Alzheimer's disease is often connected with nutritional misbalance, such as
enhanced cholesterol intake, deficiency in polyunsaturated fatty acids, or hypovitaminosis …

Background: Because cancer is a complex disease, it is unlikely that a single mono
functional 'targeted'drug will be effective for treating this most advanced disease. Combined …

Early in the age of modern medicine the consequences of vitamin A deficiency drew
attention to the fundamental link between retinoid-dependent homeostatic regulation and …

Abstract The Cytochrome P450 (CYP) family 26 enzymes contribute to retinoic acid (RA)
metabolism and homeostasis in humans, mammals and other chordates. The three CYP26 …

Abstract Background Long noncoding RNAs (lncRNAs) have been indicated to play critical
roles in cancer development and progression. LncRNA HOXD cluster antisense RNA1 …

Neuroblastoma is the most common extracranial solid tumor in infants, arising from
developmentally stalled neural crest-derived cells. Driving tumor differentiation is a …