Ubiquitination, an important type of protein posttranslational modification (PTM), plays a
crucial role in controlling substrate degradation and subsequently mediates the “quantity” …

Cellular senescence is a complex stress response that permanently arrests the proliferation
of cells at risk for oncogenic transformation. However, senescent cells can also drive …

Dynamic modulation and posttranslational modification of proteins are tightly controlled
biological processes that occur in response to physiological cues. One such dynamic …

The ubiquitin-related SUMO system controls many cellular signaling networks. In
mammalian cells, three SUMO forms (SUMO1, SUMO2 and SUMO3) act as covalent …

JCI - SENP7 senses oxidative stress to sustain metabolic fitness and antitumor functions of
CD8+ T cells Go to JCI Insight About Editors Consulting Editors For authors Publication ethics …

Despite all the other cells that have the potential to prevent cancer development and
metastasis through tumour suppressor proteins, cancer cells can upregulate the ubiquitin …

Background The gene encoding the E3 ubiquitin ligase substrate-binding adaptor SPOP is
frequently mutated in primary prostate cancer, but how SPOP mutations contribute to …

The nuclear speckle-type pox virus and zinc finger (POZ) protein (SPOP), a representative
substrate-recognition subunit of the cullin-RING E3 ligase, has been characterized to play a …

Blockade of programmed cell death 1 (PD-1)/programmed cell death 1 ligand (PD-L1) has
evolved into one of the most promising immunotherapy strategies for cancer patients. Tumor …

The initiation and progression of cancer is dependent on the acquisition of mutations in
oncogenes or tumor suppressor genes that ultimately leads to the dysregulation of key …