Recent developments of novel matrices and on-tissue chemical derivatization reagents for MALDI-MSI

Q Zhou, A Fülöp, C Hopf - Analytical and bioanalytical chemistry, 2021 - Springer
Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) is a fast-
growing technique for visualization of the spatial distribution of the small molecular and …

On‐tissue chemical derivatization in mass spectrometry imaging

C Harkin, KW Smith, FL Cruickshank… - Mass spectrometry …, 2022 - Wiley Online Library
Mass spectrometry imaging (MSI) combines molecular and spatial information in a valuable
tool for a wide range of applications. Matrix‐assisted laser desorption/ionization (MALDI) is …

Enzymatic electrochemical biosensors for neurotransmitters detection: recent achievements and trends

Z Fredj, B Singh, M Bahri, P Qin, M Sawan - Chemosensors, 2023 - mdpi.com
Neurotransmitters (NTs) play a crucial role in regulating the behavioral and physiological
functions of the nervous system. Imbalances in the concentrations of NT have been directly …

“Nano”: an emerging avenue in electrochemical detection of neurotransmitters

S Madhurantakam, JB Karnam… - ACS Chemical …, 2020 - ACS Publications
The growing importance of nanomaterials toward the detection of neurotransmitter
molecules has been chronicled in this review. Neurotransmitters (NTs) are chemicals that …

Unlocking the future of brain research: MOFs, TMOs, and MOFs/TMOs for electrochemical NTMs detection and analysis

T Iftikhar, N Iftikhar, G Chi, W Qiu, Y Xie, Z Liang… - Talanta, 2024 - Elsevier
The central nervous system relies heavily on neurotransmitters (NTMs), and NTM
imbalances have been linked to a wide range of neurological conditions. Thus, the …

Recent advances of ambient mass spectrometry imaging and its applications in lipid and metabolite analysis

K Qi, L Wu, C Liu, Y Pan - Metabolites, 2021 - mdpi.com
Ambient mass spectrometry imaging (AMSI) has attracted much attention in recent years. As
a kind of unlabeled molecular imaging technique, AMSI can enable in situ visualization of a …

Enhanced on-tissue chemical derivatization with hydrogel assistance for mass spectrometry imaging

Q Zang, M Wang, Y Zhu, L Wang, Z Luo, X Li… - Analytical …, 2021 - ACS Publications
The improvement of on-tissue chemical derivatization for mass spectrometry imaging (MSI)
of low-abundance and/or poorly ionizable functional molecules in biological tissue without …

Nanocomposite-based electrochemical sensors for neurotransmitters detection in neurodegenerative diseases

T Rajarathinam, M Kang, S Hong, SC Chang - Chemosensors, 2023 - mdpi.com
Neurotransmitters (NTs) are crucial regulatory molecules responsible for maintaining the
neurophysiological functioning of the brain. Dysregulated levels of certain NTs, such as …

基质辅助激光解吸电离-质谱成像技术(MALDI-MSI) 及其在脑神经性疾病研究中的应用

金涛, 潘本松, 聂洪港 - 计量科学与技术, 2022 - jlkj.nim.ac.cn
大脑是人体内结构最精细, 功能最复杂的高级器官, 其化学物质种类众多, 功能多样,
作用机制复杂. 研究证明, 脑中枢神经系统疾病的病变脑组织都涉及到一些神经分子的改变 …

Design and characterizing of robust probes for enhanced mass spectrometry imaging and spatially resolved metabolomics

J Huang, S Gao, K Wang, J Zhang, X Pang, J Shi… - Chinese Chemical …, 2023 - Elsevier
As for the emerging and cut edge spatially resolved metabolomics, mass spectrometry
imaging (MSI) is a powerful tool that can map thousands of metabolites from bio-tissue …