Targeting ferroptosis opens new avenues for the development of novel therapeutics
S Sun, J Shen, J Jiang, F Wang, J Min - Signal transduction and …, 2023 - nature.com
Ferroptosis is an iron-dependent form of regulated cell death with distinct characteristics,
including altered iron homeostasis, reduced defense against oxidative stress, and abnormal …
including altered iron homeostasis, reduced defense against oxidative stress, and abnormal …
N‐acetylcysteine (NAC) in neurological disorders: mechanisms of action and therapeutic opportunities
R Bavarsad Shahripour, MR Harrigan… - Brain and …, 2014 - Wiley Online Library
Background There is an expanding field of research investigating the benefits of medicines
with multiple mechanisms of action across neurological disorders. N‐acetylcysteine (NAC) …
with multiple mechanisms of action across neurological disorders. N‐acetylcysteine (NAC) …
[HTML][HTML] NAC, NAC, Knockin'on Heaven's door: Interpreting the mechanism of action of N-acetylcysteine in tumor and immune cells
B Kalyanaraman - Redox Biology, 2022 - Elsevier
N-acetylcysteine (NAC) has been used as a direct scavenger of reactive oxygen species
(hydrogen peroxide, in particular) and an antioxidant in cancer biology and immuno …
(hydrogen peroxide, in particular) and an antioxidant in cancer biology and immuno …
N-acetylcysteine in a Double-Blind Randomized Placebo-Controlled Trial: Toward Biomarker-Guided Treatment in Early Psychosis
Biomarker-guided treatments are needed in psychiatry, and previous data suggest oxidative
stress may be a target in schizophrenia. A previous add-on trial with the antioxidant N …
stress may be a target in schizophrenia. A previous add-on trial with the antioxidant N …
Development of chitosan-coated liposome for pulmonary delivery of N-acetylcysteine
H Hamedinasab, AH Rezayan, M Mellat… - International journal of …, 2020 - Elsevier
The purpose of the present investigation was to formulate NAC (N-acetylcysteine)-loaded
chitosan (CH)-coated liposome aiming at obtaining an effective formulation able to ensure a …
chitosan (CH)-coated liposome aiming at obtaining an effective formulation able to ensure a …
Direct Interaction between N-Acetylcysteine and Cytotoxic Electrophile—An Overlooked In Vitro Mechanism of Protection
P Mlejnek - Antioxidants, 2022 - mdpi.com
In laboratory experiments, many electrophilic cytotoxic agents induce cell death
accompanied by reactive oxygen species (ROS) production and/or by glutathione (GSH) …
accompanied by reactive oxygen species (ROS) production and/or by glutathione (GSH) …
Inherited retinal dystrophies: role of oxidative stress and inflammation in their physiopathology and therapeutic implications
I Pinilla, V Maneu, L Campello, L Fernández-Sánchez… - Antioxidants, 2022 - mdpi.com
Inherited retinal dystrophies (IRDs) are a large group of genetically and clinically
heterogeneous diseases characterized by the progressive degeneration of the retina …
heterogeneous diseases characterized by the progressive degeneration of the retina …
Mitochondria: a Promising Convergent Target for the treatment of amyotrophic lateral sclerosis
T Cunha-Oliveira, L Montezinho, RF Simões… - Cells, 2024 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease
characterized by the progressive loss of motor neurons, for which current treatment options …
characterized by the progressive loss of motor neurons, for which current treatment options …
Potential Role of N-Acetylcysteine in the Management of Substance Use Disorders
There is a clear and pressing need to expand pharmacotherapy options for substance use
disorders (SUDs) in order to improve sustained abstinence outcomes. Preclinical literature …
disorders (SUDs) in order to improve sustained abstinence outcomes. Preclinical literature …
Drug addiction: a curable mental disorder?
J Liu, J Li - Acta Pharmacologica Sinica, 2018 - nature.com
Drug addiction is a chronic, relapsing brain disorder. Multiple neural networks in the brain
including the reward system (eg, the mesocorticolimbic system), the anti-reward/stress …
including the reward system (eg, the mesocorticolimbic system), the anti-reward/stress …