Ferroptosis is an iron-dependent form of regulated cell death with distinct characteristics,
including altered iron homeostasis, reduced defense against oxidative stress, and abnormal …

Background There is an expanding field of research investigating the benefits of medicines
with multiple mechanisms of action across neurological disorders. N‐acetylcysteine (NAC) …

N-acetylcysteine (NAC) has been used as a direct scavenger of reactive oxygen species
(hydrogen peroxide, in particular) and an antioxidant in cancer biology and immuno …

Biomarker-guided treatments are needed in psychiatry, and previous data suggest oxidative
stress may be a target in schizophrenia. A previous add-on trial with the antioxidant N …

The purpose of the present investigation was to formulate NAC (N-acetylcysteine)-loaded
chitosan (CH)-coated liposome aiming at obtaining an effective formulation able to ensure a …

In laboratory experiments, many electrophilic cytotoxic agents induce cell death
accompanied by reactive oxygen species (ROS) production and/or by glutathione (GSH) …

Inherited retinal dystrophies (IRDs) are a large group of genetically and clinically
heterogeneous diseases characterized by the progressive degeneration of the retina …

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease
characterized by the progressive loss of motor neurons, for which current treatment options …

There is a clear and pressing need to expand pharmacotherapy options for substance use
disorders (SUDs) in order to improve sustained abstinence outcomes. Preclinical literature …

Drug addiction is a chronic, relapsing brain disorder. Multiple neural networks in the brain
including the reward system (eg, the mesocorticolimbic system), the anti-reward/stress …