Nucleic acid hybridization with a labeled probe is the only practical way to detect a
complementary target sequence in a complex nucleic acid mixture. The first section of this …

The formation of canonical base pairs through Watson–Crick hydrogen bonding sits at the
heart of the genetic apparatus. The specificity of the base pairing of adenine with …

DNA modifications vary in form and function but generally do not alter Watson-Crick base
pairing. Diaminopurine (Z) is an exception because it completely replaces adenine and …

The key step in bacterial promoter opening is recognition of the− 10 promoter element (T−
12 A− 11 T− 10 A− 9 A− 8 T− 7 consensus sequence) by the RNA polymerase σ subunit. We …

The synthesis of modified oligonucleotides by the phosphoramidite approach and their
applications - ScienceDirect Skip to main contentSkip to article Elsevier logo Journals & Books …

Genomic DNA of the cyanophage S-2L virus is composed of 2-aminoadenine (Z), thymine
(T), guanine (G), and cytosine (C), forming the genetic alphabet ZTGC, which violates …

Until a few decades ago, molecules that exert a therapeutic effect on the human body were
exclusively discovered byserendipity. As our understanding of molecular biology is …

Although simple in concept, PCR requires a myriad of complex interactions between
template, primers, deoxynucleoside triphosphates, and DNA polymerase to successfully …

A pair of complementary oligodeoxynucleotides (ODNs) uniformly substituted with 2-
aminoadenine (A ') in place of adenine and 2-thiothymine (T ') in place of thymine did not …

In this review we describe the influence of modified nucleobases in order to understand the
changes they introduce in double and triple helix forming oligomers with the aim to study …