Medicinal attributes of pyrazolo [3, 4-d] pyrimidines: a review
M Chauhan, R Kumar - Bioorganic & medicinal chemistry, 2013 - Elsevier
Pyrazolopyrimidines are the fused heterocyclic ring systems which structurally resemble
purines which prompted biological investigations to assess their potential therapeutic …
purines which prompted biological investigations to assess their potential therapeutic …
Progress of the synthesis of condensed pyrazole derivatives (from 2010 to mid-2013)
M Li, BX Zhao - European Journal of Medicinal Chemistry, 2014 - Elsevier
Condensed pyrazole derivatives are important heterocyclic compounds due to their
excellent biological activities and have been widely applied in pharmaceutical and …
excellent biological activities and have been widely applied in pharmaceutical and …
[HTML][HTML] Targeting tumor cells with pyrazolo [3, 4-d] pyrimidine scaffold: A literature review on synthetic approaches, structure activity relationship, structural and target …
Abstract Pyrazolo [3, 4-d] pyrimidine had been attracted awesome interest due to its
pharmacological potential especially as an anticancer. Several mechanisms of action were …
pharmacological potential especially as an anticancer. Several mechanisms of action were …
Synthesis and anticancer effects of some novel pyrazolo [3, 4-d] pyrimidine derivatives by generating reactive oxygen species in human breast adenocarcinoma cells
AE Rashad, AE Mahmoud, MM Ali - European journal of medicinal …, 2011 - Elsevier
A series of novel substituted pyrazolo [3, 4-d] pyrimidines (compounds 2–12) were
synthesized starting with pyrimidinone derivative 1. Their in vitro cytotoxicity against human …
synthesized starting with pyrimidinone derivative 1. Their in vitro cytotoxicity against human …
Synthesis and biological evaluation of novel pyrazolopyrimidines derivatives as anticancer and anti-5-lipoxygenase agents
A Rahmouni, S Souiei, MA Belkacem, A Romdhane… - Bioorganic …, 2016 - Elsevier
A novel series of 6-aryl-3-methyl-1-phenyl-1H-pyrazolo [3, 4-d] pyrimidin-4 (5H)-ones 3a-h
were synthesized in a single step via condensation of carboxamide 2 with some aromatic …
were synthesized in a single step via condensation of carboxamide 2 with some aromatic …
New advances in synthesis and clinical aspects of pyrazolo [3, 4-d] pyrimidine scaffolds
KRA Abdellatif, RB Bakr - Bioorganic Chemistry, 2018 - Elsevier
Abstract Pyrazolo [3, 4-d] pyrimidine ring system constitute an important class of heterocyclic
compounds which can serve as a promising scaffold exhibiting many pharmacological …
compounds which can serve as a promising scaffold exhibiting many pharmacological …
Design, synthesis, and biological evaluation with molecular dynamics study of novel pyrazolo [3, 4-d] pyrimidine derivatives as anti-cancer agents
In continuation of our efforts to discover new structural chemotypes with significant
chemotherapeutic activities, a novel series of pyrazolo [3, 4-d] pyrimidine-based compounds …
chemotherapeutic activities, a novel series of pyrazolo [3, 4-d] pyrimidine-based compounds …
Pyrazolo[3,4‐d]pyrimidine scaffold: A review on synthetic approaches and EGFR and VEGFR inhibitory activities
AE Kassab - Archiv der Pharmazie, 2023 - Wiley Online Library
Abstract The pyrazolo [3, 4‐d] pyrimidine core has received a lot of interest from the
medicinal chemistry community as a promising framework for drug design and discovery. It …
medicinal chemistry community as a promising framework for drug design and discovery. It …
Design, synthesis, docking, and antimicrobial evaluation of some novel pyrazolo[1,5-a] pyrimidines and their corresponding cycloalkane ring-fused derivatives as …
AEM Abdallah, GH Elgemeie - drug design, development and …, 2018 - Taylor & Francis
Background Over the years, pyrazolopyrimidine derivatives have been recognized as
having antimicrobial activities. Recently, we reported different synthetic methods to prepare …
having antimicrobial activities. Recently, we reported different synthetic methods to prepare …
Synthesis and in vitro antibacterial evaluation of 6-substituted 4-amino-pyrazolo[3,4-d]pyrimidines
Abstract Pyrazolo [3, 4-d] pyrimidines are one of the most important classes of fused
heterocyclic compounds which exhibit a broad range of biological and medicinal properties …
heterocyclic compounds which exhibit a broad range of biological and medicinal properties …