From haematopoietic stem cells to complex differentiation landscapes
E Laurenti, B Göttgens - Nature, 2018 - nature.com
The development of mature blood cells from haematopoietic stem cells has long served as a
model for stem-cell research, with the haematopoietic differentiation tree being widely used …
model for stem-cell research, with the haematopoietic differentiation tree being widely used …
Circular RNA-encoded oncogenic E-cadherin variant promotes glioblastoma tumorigenicity through activation of EGFR–STAT3 signalling
Activated EGFR signalling drives tumorigenicity in 50% of glioblastoma (GBM). However,
EGFR-targeting therapy has proven ineffective in treating patients with GBM, indicating that …
EGFR-targeting therapy has proven ineffective in treating patients with GBM, indicating that …
The development of T cells from stem cells in mice and humans
F Famili, AS Wiekmeijer, FJT Staal - Future science OA, 2017 - Taylor & Francis
T cells develop from hematopoietic stem cells in the specialized microenvironment of the
thymus. The main transcriptional players of T-cell differentiation such as Notch, Tcf-1, Gata3 …
thymus. The main transcriptional players of T-cell differentiation such as Notch, Tcf-1, Gata3 …
Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells
Both intrinsic cell state changes and variations in the composition of stem cell populations
have been implicated as contributors to aging. We used single-cell RNA-seq to dissect …
have been implicated as contributors to aging. We used single-cell RNA-seq to dissect …
The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress
The blood system is sustained by a pool of haematopoietic stem cells (HSCs) that are long-
lived due to their capacity for self-renewal. A consequence of longevity is exposure to stress …
lived due to their capacity for self-renewal. A consequence of longevity is exposure to stress …
Human and murine hematopoietic stem cell aging is associated with functional impairments and intrinsic megakaryocytic/erythroid bias
A Rundberg Nilsson, S Soneji, S Adolfsson, D Bryder… - PloS one, 2016 - journals.plos.org
Aging within the human hematopoietic system associates with various deficiencies and
disease states, including anemia, myeloid neoplasms and reduced adaptive immune …
disease states, including anemia, myeloid neoplasms and reduced adaptive immune …
Single-cell analysis reveals regulatory gene expression dynamics leading to lineage commitment in early T cell development
Intrathymic T cell development converts multipotent precursors to committed pro-T cells,
silencing progenitor genes while inducing T cell genes, but the underlying steps have …
silencing progenitor genes while inducing T cell genes, but the underlying steps have …
Myelo-lymphoid lineage restriction occurs in the human haematopoietic stem cell compartment before lymphoid-primed multipotent progenitors
S Belluschi, EF Calderbank, V Ciaurro… - Nature …, 2018 - nature.com
Capturing where and how multipotency is lost is crucial to understand how blood formation
is controlled. Blood lineage specification is currently thought to occur downstream of …
is controlled. Blood lineage specification is currently thought to occur downstream of …
Choroid plexus‐derived miR‐204 regulates the number of quiescent neural stem cells in the adult brain
T Lepko, M Pusch, T Müller, D Schulte, J Ehses… - The EMBO …, 2019 - embopress.org
Regulation of adult neural stem cell (NSC) number is critical for lifelong neurogenesis. Here,
we identified a post‐transcriptional control mechanism, centered around the micro RNA 204 …
we identified a post‐transcriptional control mechanism, centered around the micro RNA 204 …
EBF1 primes B-lymphoid enhancers and limits the myeloid bias in murine multipotent progenitors
Hematopoietic stem cells (HSCs) and multipotent progenitors (MPPs) generate all cells of
the blood system. Despite their multipotency, MPPs display poorly understood lineage bias …
the blood system. Despite their multipotency, MPPs display poorly understood lineage bias …