Genetic correlations between Alzheimer's disease and gut microbiome genera

D Cammann, Y Lu, MJ Cummings, ML Zhang… - Scientific Reports, 2023 - nature.com
A growing body of evidence suggests that dysbiosis of the human gut microbiota is
associated with neurodegenerative diseases like Alzheimer's disease (AD) via …

Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity

JB Harley, X Chen, M Pujato, D Miller, A Maddox… - Nature …, 2018 - nature.com
Explaining the genetics of many diseases is challenging because most associations localize
to incompletely characterized regulatory regions. Using new computational methods, we …

Genomic and transcriptomic association studies identify 16 novel susceptibility loci for venous thromboembolism

S Lindström, LU Wang, EN Smith… - Blood, The Journal …, 2019 - ashpublications.org
Venous thromboembolism (VTE) is a significant contributor to morbidity and mortality. To
advance our understanding of the biology contributing to VTE, we conducted a genome …

SumHer better estimates the SNP heritability of complex traits from summary statistics

D Speed, DJ Balding - Nature genetics, 2019 - nature.com
We present SumHer, software for estimating confounding bias, SNP heritability, enrichments
of heritability and genetic correlations using summary statistics from genome-wide …

The phenotypic legacy of admixture between modern humans and Neandertals

CN Simonti, B Vernot, L Bastarache, E Bottinger… - Science, 2016 - science.org
Many modern human genomes retain DNA inherited from interbreeding with archaic
hominins, such as Neandertals, yet the influence of this admixture on human traits is largely …

Insights into the genetic architecture of the human face

JD White, K Indencleef, S Naqvi, RJ Eller, H Hoskens… - Nature …, 2021 - nature.com
The human face is complex and multipartite, and characterization of its genetic architecture
remains challenging. Using a multivariate genome-wide association study meta-analysis of …

Meta-analysis of genome-wide association studies for abdominal aortic aneurysm identifies four new disease-specific risk loci

GT Jones, G Tromp, H Kuivaniemi… - Circulation …, 2017 - Am Heart Assoc
Rationale: Abdominal aortic aneurysm (AAA) is a complex disease with both genetic and
environmental risk factors. Together, 6 previously identified risk loci only explain a small …

High heritability of ascending aortic diameter and trans-ancestry prediction of thoracic aortic disease

C Tcheandjieu, K Xiao, H Tejeda, JA Lynch… - Nature Genetics, 2022 - nature.com
Enlargement of the aorta is an important risk factor for aortic aneurysm and dissection, a
leading cause of morbidity in the developed world. Here we performed automated extraction …

High-density genotyping of immune-related loci identifies new SLE risk variants in individuals with Asian ancestry

C Sun, JE Molineros, LL Looger, X Zhou, K Kim… - Nature …, 2016 - nature.com
Systemic lupus erythematosus (SLE) has a strong but incompletely understood genetic
architecture. We conducted an association study with replication in 4,478 SLE cases and …

[HTML][HTML] Lessons learned from the eMERGE Network: balancing genomics in discovery and practice

eMERGE Consortium - Human Genetics and Genomics Advances, 2021 - Elsevier
Summary The Electronic Medical Records and Genomics (eMERGE) Network, established
in 2007, is a consortium of academic and integrated health systems conducting discovery …