Genetic correlations between Alzheimer's disease and gut microbiome genera
D Cammann, Y Lu, MJ Cummings, ML Zhang… - Scientific Reports, 2023 - nature.com
A growing body of evidence suggests that dysbiosis of the human gut microbiota is
associated with neurodegenerative diseases like Alzheimer's disease (AD) via …
associated with neurodegenerative diseases like Alzheimer's disease (AD) via …
Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity
Explaining the genetics of many diseases is challenging because most associations localize
to incompletely characterized regulatory regions. Using new computational methods, we …
to incompletely characterized regulatory regions. Using new computational methods, we …
Genomic and transcriptomic association studies identify 16 novel susceptibility loci for venous thromboembolism
Venous thromboembolism (VTE) is a significant contributor to morbidity and mortality. To
advance our understanding of the biology contributing to VTE, we conducted a genome …
advance our understanding of the biology contributing to VTE, we conducted a genome …
SumHer better estimates the SNP heritability of complex traits from summary statistics
D Speed, DJ Balding - Nature genetics, 2019 - nature.com
We present SumHer, software for estimating confounding bias, SNP heritability, enrichments
of heritability and genetic correlations using summary statistics from genome-wide …
of heritability and genetic correlations using summary statistics from genome-wide …
The phenotypic legacy of admixture between modern humans and Neandertals
Many modern human genomes retain DNA inherited from interbreeding with archaic
hominins, such as Neandertals, yet the influence of this admixture on human traits is largely …
hominins, such as Neandertals, yet the influence of this admixture on human traits is largely …
Insights into the genetic architecture of the human face
The human face is complex and multipartite, and characterization of its genetic architecture
remains challenging. Using a multivariate genome-wide association study meta-analysis of …
remains challenging. Using a multivariate genome-wide association study meta-analysis of …
Meta-analysis of genome-wide association studies for abdominal aortic aneurysm identifies four new disease-specific risk loci
Rationale: Abdominal aortic aneurysm (AAA) is a complex disease with both genetic and
environmental risk factors. Together, 6 previously identified risk loci only explain a small …
environmental risk factors. Together, 6 previously identified risk loci only explain a small …
High heritability of ascending aortic diameter and trans-ancestry prediction of thoracic aortic disease
Enlargement of the aorta is an important risk factor for aortic aneurysm and dissection, a
leading cause of morbidity in the developed world. Here we performed automated extraction …
leading cause of morbidity in the developed world. Here we performed automated extraction …
High-density genotyping of immune-related loci identifies new SLE risk variants in individuals with Asian ancestry
Systemic lupus erythematosus (SLE) has a strong but incompletely understood genetic
architecture. We conducted an association study with replication in 4,478 SLE cases and …
architecture. We conducted an association study with replication in 4,478 SLE cases and …
[HTML][HTML] Lessons learned from the eMERGE Network: balancing genomics in discovery and practice
eMERGE Consortium - Human Genetics and Genomics Advances, 2021 - Elsevier
Summary The Electronic Medical Records and Genomics (eMERGE) Network, established
in 2007, is a consortium of academic and integrated health systems conducting discovery …
in 2007, is a consortium of academic and integrated health systems conducting discovery …