Automated chemical oligosaccharide synthesis: novel approach to traditional challenges
Advances in carbohydrate chemistry have certainly made common oligosaccharides much
more accessible. However, many current methods still rely heavily upon specialized …
more accessible. However, many current methods still rely heavily upon specialized …
Synthesis and glycosidation of anomeric halides: evolution from early studies to modern methods of the 21st century
Y Singh, SA Geringer, AV Demchenko - Chemical reviews, 2022 - ACS Publications
Advances in synthetic carbohydrate chemistry have dramatically improved access to
common glycans. However, many novel methods still fail to adequately address challenges …
common glycans. However, many novel methods still fail to adequately address challenges …
Glycans and glycoproteins as specific biomarkers for cancer
Protein glycosylation and other post-translational modifications are involved in potentially all
aspects of human growth and development. Defective glycosylation has adverse effects on …
aspects of human growth and development. Defective glycosylation has adverse effects on …
Glycomics and disease markers
HJ An, SR Kronewitter, MLA de Leoz… - Current opinion in …, 2009 - Elsevier
Glycomics is the comprehensive study of all glycans expressed in biological systems. The
biosynthesis of glycan relies on a number of highly competitive processes involving glycosyl …
biosynthesis of glycan relies on a number of highly competitive processes involving glycosyl …
High resolution mass spectrometry based techniques at the crossroads of metabolic pathways
C Junot, F Fenaille, B Colsch… - Mass spectrometry …, 2014 - Wiley Online Library
The metabolome is the set of small molecular mass compounds found in biological media,
and metabolomics, which refers to as the analysis of metabolome in a given biological …
and metabolomics, which refers to as the analysis of metabolome in a given biological …
Alternative glycosylation modulates function of IgG and other proteins—implications on evolution and disease
BACKGROUND: Nearly all membrane and secreted proteins, as well as numerous
intracellular proteins are glycosylated. However, contrary to proteins which are defined by …
intracellular proteins are glycosylated. However, contrary to proteins which are defined by …
Hydrogen/deuterium exchange in mass spectrometry
The isotopic exchange approach is in use since the first observation of such reactions in
1933 by Lewis. This approach allows the investigation of the pathways of chemical and …
1933 by Lewis. This approach allows the investigation of the pathways of chemical and …
Glycosylation of plasma IgG in colorectal cancer prognosis
In this study we demonstrate the potential value of Immunoglobulin G (IgG) glycosylation as
a novel prognostic biomarker of colorectal cancer (CRC). We analysed plasma IgG glycans …
a novel prognostic biomarker of colorectal cancer (CRC). We analysed plasma IgG glycans …
Decreased core-fucosylation contributes to malignancy in gastric cancer
YP Zhao, XY Xu, M Fang, H Wang, Q You, CH Yi, J Ji… - PloS one, 2014 - journals.plos.org
The object of the study is to identify N-glycan profiling changes associated with gastric
cancer and explore the impact of core-fucosylation on biological behaviors of human gastric …
cancer and explore the impact of core-fucosylation on biological behaviors of human gastric …
Gastric cancer: adding glycosylation to the equation
Gastric cancer has a high incidence and mortality, so there is a pressing need to understand
the underlying molecular mechanisms in order to discover novel biomarkers. Glycosylation …
the underlying molecular mechanisms in order to discover novel biomarkers. Glycosylation …