Aptamers are single-stranded nucleic acid sequences that can bind to target molecules with
high selectivity and affinity. Most aptamers are screened in vitro by a combinatorial biology …

Major depressive disorder (MDD) is a chronic, generally episodic and debilitating disease
that affects an estimated 300 million people worldwide, but its pathogenesis is poorly …

Neuropsychiatric disease frequently presents with an underlying hyporeactivity or
hyperreactivity of the HPA stress axis, suggesting an exceptional vulnerability of this circuitry …

Regulation of viral RNA biogenesis is fundamental to productive SARS-CoV-2 infection. To
characterize host RNA-binding proteins (RBPs) involved in this process, we biochemically …

Long noncoding RNAs participate in the progression and initiation of non‐small cell lung
cancer (NSCLC), although the mechanism remains unknown. The lncRNA identified as …

Bone mass is maintained by the balance between osteoclast-induced bone resorption and
osteoblast-triggered bone formation. In inflammatory arthritis such as rheumatoid arthritis …

Metastatic breast cancer is a leading health burden worldwide. Previous studies have
shown that metadherin (MTDH) promotes breast cancer initiation, metastasis and therapy …

Since its initial identification and cloning in 2002, Astrocyte Elevated Gene-1 (AEG-1), also
known as metadherin (MTDH), 3D3 and LYsine-RIch CEACAM1 co-isolated (LYRIC), has …

Abstract SND1 is an AEG-1/MTDH/LYRIC-binding protein that is upregulated in numerous
human cancers, where it has been assigned multiple functional roles. In this study, we report …

Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit
maps are increasingly available, knowledge of their underlying molecular networks remains …