Abstract Merlin (Moesin-ezrin-radixin-like protein, also known as schwannomin) is a tumor
suppressor protein encoded by the neurofibromatosis type 2 gene NF2. Loss of function …

Neurofibromatosis type II (NF2) is a tumor predisposition syndrome characterized by the
development of distinctive nervous system lesions. NF2 results from loss-of-function …

Neurofibromatosis (NF) encompasses a group of distinct genetic disorders in which affected
children and adults are prone to the development of benign and malignant tumors of the …

Loss of the Merlin tumor suppressor and activation of the Hippo signaling pathway play
major roles in the control of cell proliferation and tumorigenesis. We have identified …

Vestibular schwannomas are tumors arising from the vestibulocochlear nerve at the
cerebellopontine angle. Their proximity to eloquent brainstem structures means that the …

Malignant peripheral nerve sheath tumors (MPNSTs) are highly aggressive Schwann cell
(SC)-lineage-derived sarcomas. Molecular events driving SC-to-MPNST transformation are …

Abstract Neurofibromatosis type 2 (NF2) is a genetic condition marked by the development
of multiple benign tumors in the nervous system. The most common tumors associated with …

Neurofibromatosis Type 2 (NF2) is an autosomal dominant genetic syndrome caused by
mutations in the NF2 tumor suppressor gene resulting in multiple schwannomas and …

Schwannoma tumours typically arise on the eighth cranial nerve and are mostly caused by
loss of the tumour suppressor Merlin (NF2). There are no approved chemotherapies for …

Schwannomas are predominantly benign nerve sheath neoplasms caused by Nf2 gene
inactivation. Presently, treatment options are mainly limited to surgical tumor resection due …