Immune responses to Mycobacterium tuberculosis are only partially effective; they drive the
bacteria into a latent state, but rarely eliminate them. Unfortunately, the latent state of M …

Tuberculosis, caused by the pathogenic bacterium Mycobacterium tuberculosis (Mtb), is the
leading cause of death from an infectious disease, with a mortality rate of over a million …

Tuberculosis (TB), one of the oldest known human diseases. is still is one of the major
causes of mortality, since two million people die each year from this malady. TB has many …

Tuberculosis is primarily a disease of the lung, and dissemination of the disease depends
on productive infection of this critical organ. Upon aerosol infection with Mycobacterium …

By virtue of their position at the crossroads between the innate and adaptive immune
response, macrophages play an essential role in the control of bacterial infections …

Phagocytosis of tubercle bacilli by antigen-presenting cells in human lung alveoli initiates a
complex infection process by Mycobacterium tuberculosis and a potentially protective …

The different manifestations of infection with Mycobacterium tuberculosis reflect the balance
between the bacillus and host defense mechanisms. Traditionally, protective immunity to …

Mycobacterium tuberculosis survives in antigen-presenting cells (APCs) such as
macrophages and dendritic cells. APCs present antigens in association with major …

The onset of the adaptive immune response to Mycobacterium tuberculosis is delayed
compared with that of other infections or immunization, and allows the bacterial population …

New tools for controlling tuberculosis are urgently needed. Despite our emerging
understanding of the biogeography of Mycobacterium tuberculosis, the implications for …