The alterations in myocardial energy substrate metabolism that occur in heart failure, and
the causes and consequences of these abnormalities, are poorly understood. There is …

The transporters regulating the uptake of glucose belong to the GLUT family17–19 and
constitute a system of stereospecific and saturable transport/countertransport. The isoform …

We determined whether high fatty acid oxidation rates during aerobic reperfusion of
ischemic hearts could be explained by a decrease in malonyl-CoA levels, which would …

First, we present a summary of the evidence for our model of the molecular mechanism of
the permeability transition (MPT). Our proposal is that the MPT occurs as a result of the …

Heart tissue is remarkably sensitive to oxygen deprivation. Although heart cells, like those of
most tissues, rapidly adapt to anoxic conditions, relatively short periods of ischaemia and …

An Imbalance between Glycolysis and Glucose Oxidation Is a Possible Explanation for the
Detrimental Effects of High Levels of Fa Page 1 Vol. 264, No. 1 Printed in USA ABSTRACT …

To investigate whether the energy derived from glycolysis is functionally coupled to Ca2+
active transport in sarcoplasmic reticulum (SR), we determined whether glycolytic enzymes …

Oxidative stress is implicated in neurodegenerative diseases including stroke, Alzheimer's
disease and Parkinson's disease, and has been extensively studied as a potential target for …

Cardiac efficiency is decreased in hearts after severe ischemia. We determined whether
reducing the production of H+ from glucose metabolism or inhibiting the clearance of H+ via …

In response to a prolonged pressure-or volume-overload, alterations occur in myocardial
fatty acid, glucose, and glycogen metabolism. Oxidation of long chain fatty acids has been …