The endoplasmic reticulum (ER) is a major site for protein synthesis, folding, and maturation
in eukaryotic cells, responsible for production of secretory proteins and most integral …

Looking at the variety of the thousands of different polypeptides that have been focused on
in the research on the endoplasmic reticulum from the last five decades taught us one …

Abstract α-Helical integral membrane proteins comprise approximately 25% of the proteome
in all organisms. The membrane proteome is highly diverse, varying in the number …

Membrane topology refers to the two-dimensional structural information of a membrane
protein that indicates the number of transmembrane (TM) segments and the orientation of …

Cells have developed an incredible machinery to facilitate the insertion of membrane
proteins into the membrane. While we have a fairly good understanding of the mechanism …

Signal sequences play a key role during the first steps of the intracellular transport of G
protein-coupled receptors (GPCRs). They are involved in targeting of the nascent chains to …

Protein translocation across the bacterial cytoplasmic membrane is an essential process
catalyzed by the Sec translocase, which in its minimal form consists of the protein …

Here, we review recent molecular modelling and simulation studies of the Sec translocon,
the primary component/channel of protein translocation into the endoplasmic reticulum (ER) …

The Sec complex catalyzes the translocation of proteins of the secretory pathway into the
endoplasmic reticulum and the integration of membrane proteins into the endoplasmic …

The chaperone BiP participates in several regulatory processes within the endoplasmic
reticulum (ER): translocation, protein folding, and ER-associated degradation. To facilitate …