Polycyclic aromatic hydrocarbons (PAHs) and heterocyclic aromatic compounds (HACs)
constitute a major class of chemical carcinogens present in the environment. These …

Attesting to the spectacular growth in the field of structural biology, the total number of
coordinate files deposited in the Protein Data Bank was rapidly approaching 30 000 entries …

The key characteristic (KCs) framework has been used previously to assess the
carcinogenicity and cardiotoxicity of various chemical and pharmacological agents. Here …

Arylamines and polycyclic aromatic hydrocarbons (PAHs), which are known as “bulky”
carcinogens, have been studied extensively and upon activation in vivo, react with cellular …

This review continues a general presentation of the metabolism of drugs and other
xenobiotics begun in five recent issues of Chemistry & Biodiversity. The present Part is …

It is well known that CpG dinucleotide steps in DNA, which are highly methylated at the 5-
position of cytosine (meC) in human tissues, exhibit a disproportionate number of mutations …

Noncovalent complexes of a tumorigenic benzo [a] pyrene diol epoxide with the guanine−
cytosine (GC) and adenine− thymine (AT) base pairs have been examined …

Metabolic activation of the carcinogenic tobacco-specific nitrosamines 4-(methylnitrosamino)-
1-(3-pyridyl)-1-butanone (NNK, 1) and N′-nitrosonornicotine (NNN, 2) results in the …

Les Hydrocarbures Aromatiques Polycycliques (HAP) sont une famille de polluants
atmosphériques issus de la combustion incomplète de la matière organique. Le chauffage …

Six water molecules have been used for microsolvation to outline a hydrogen bonded
network around complexes of ethylene epoxide with nucleotide bases adenine (EAw) …