Macroautophagy is a conserved catabolic process observed in all eukaryotic cells, during
which selected cellular components are transported to and broken down within lysosomes …

Macroautophagy involves the sequestration of cytoplasmic contents in a double-membrane
autophagosome and their delivery to lysosomes for degradation. In multicellular organisms …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Macroautophagy/autophagy is an essential, conserved self-eating process that cells perform
to allow degradation of intracellular components, including soluble proteins, aggregated …

Lysosomes are highly dynamic organelles that can move rapidly throughout the cell. They
distribute in a rather immobile pool located around the microtubule‐organizing center in a …

Actin cytoskeleton dynamics play vital roles in most forms of intracellular trafficking by
promoting the biogenesis and transport of vesicular cargoes. Mounting evidence indicates …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that is
characterized by selective loss of motor neurons in brain and spinal cord. TAR DNA‐binding …

Myosin-I molecular motors are proposed to play various cellular roles related to membrane
dynamics and trafficking. In this Cell Science at a Glance article and the accompanying …

Macroautophagy is an intracellular pathway used for targeting of cellular components to the
lysosome for their degradation and involves sequestration of cytoplasmic material into …

Phosphoinositides are a collection of lipid messengers that regulate most subcellular
processes. Amongst the seven phosphoinositide species, the roles for phosphatidylinositol …