Calcineurin, also known as PP2B or PPP3, is a member of the PPP family of protein
phosphatases that also includes PP1 and PP2A. Together these three phosphatases …

Congenital heart defects (CHD) are the most common congenital abnormality, with an
overall global birth prevalence of 9.41 per 1000 live births. The etiology of CHDs is complex …

Dynamic contacts are formed between endoplasmic reticulum (ER) and mitochondria that
enable the exchange of calcium and phospholipids. Disturbed contacts between ER and …

Turner syndrome (TS) is a chromosomal disorder caused by complete or partial loss of the
second sex chromosome and exhibits phenotypic heterogeneity, even after accounting for …

The unfolded protein response (UPR) is associated with the hepatic metabolic function, yet it
is not well understood how endoplasmic reticulum (ER) disturbance might influence …

Carcass traits play important roles in the broiler industry and single nucleotide
polymorphism (SNP) can be efficient molecular markers for marker-assisted breeding of …

CRELD2, a member of the cysteine-rich epidermal growth factor-like domain (CRELD)
protein family, is both an endoplasmic reticulum (ER)-resident protein and a secretory factor …

Purpose We sought to delineate a multisystem disorder caused by recessive cysteine-rich
with epidermal growth factor–like domains 1 (CRELD1) gene variants. Methods The impact …

Errors in embryonic cardiac development are a leading cause of congenital heart defects
(CHDs), including morphological abnormalities of the heart that are often detected after birth …

Objective To explore the expression of CRELD2 at the gene and protein levels of mouse
tissues, and to provide a reference for studying the biological function of CRELD2 in various …