Allergen immunotherapy in children user's guide

M Alvaro‐Lozano, CA Akdis, M Akdis… - Pediatric allergy and …, 2020 - Wiley Online Library
Allergen immunotherapy is a cornerstone in the treatment of allergic children. The clinical
efficiency relies on a well‐defined immunologic mechanism promoting regulatory T cells and …

Non‐specific lipid‐transfer proteins: Allergen structure and function, cross‐reactivity, sensitization, and epidemiology

IJ Skypala, R Asero, D Barber, L Cecchi… - Clinical and …, 2021 - Wiley Online Library
Background Discovered and described 40 years ago, non‐specific lipid transfer proteins
(nsLTP) are present in many plant species and play an important role protecting plants from …

EAACI molecular allergology user's guide 2.0

S Dramburg, C Hilger, AF Santos… - Pediatric Allergy and …, 2023 - Wiley Online Library
Since the discovery of immunoglobulin E (IgE) as a mediator of allergic diseases in 1967,
our knowledge about the immunological mechanisms of IgE‐mediated allergies has …

Molecular allergology and its impact in specific allergy diagnosis and therapy

D Barber, A Diaz‐Perales, MM Escribese… - Allergy, 2021 - Wiley Online Library
Progressive knowledge of allergenic structures resulted in a broad availability of allergenic
molecules for diagnosis. Component‐resolved diagnosis allowed a better understanding of …

Multi‐omics analysis points to altered platelet functions in severe food‐associated respiratory allergy

D Obeso, L Mera‐Berriatua, J Rodríguez‐Coira… - Allergy, 2018 - Wiley Online Library
Background Prevalence and severity of allergic diseases have increased worldwide. To
date, respiratory allergy phenotypes are not fully characterized and, along with inflammation …

The importance of metabolism for immune homeostasis in allergic diseases

J Rodriguez-Coira, A Villaseñor, E Izquierdo… - Frontiers in …, 2021 - frontiersin.org
There is increasing evidence that the metabolic status of T cells and macrophages is
associated with severe phenotypes of chronic inflammation, including allergic inflammation …

Persistent regulatory T‐cell response 2 years after 3 years of grass tablet SLIT: Links to reduced eosinophil counts, sIgE levels, and clinical benefit

R Varona, T Ramos, MM Escribese, L Jimeno… - Allergy, 2019 - Wiley Online Library
Background In the first 2 years of grass tablet sublingual immunotherapy treatment, we have
previously demonstrated a progressive development of a regulatory T‐cell response, which …

Exploring novel systemic biomarker approaches in grass‐pollen sublingual immunotherapy using omics

TC Barker‐Tejeda, R Bazire, D Obeso… - Allergy, 2021 - Wiley Online Library
Background Sublingual allergen‐specific immunotherapy (SLIT) intervention improves the
control of grass pollen allergy by maintaining allergen tolerance after cessation. Despite its …

A qualitative and quantitative comparison of IgE antibody profiles with two multiplex platforms for component‐resolved diagnostics in allergic patients

E Scala, E Caprini, D Abeni… - Clinical & …, 2021 - Wiley Online Library
Background Clinically complex phenotypes require more and more sophisticated and
comprehensive diagnostic approaches, able to discriminate genuine sensitizations from …

Celiac disease causes epithelial disruption and regulatory T cell recruitment in the oral mucosa

J Sanchez-Solares, L Sanchez… - Frontiers in …, 2021 - frontiersin.org
Celiac disease (CD) is a chronic autoimmune disease characterized by an immune-
triggered enteropathy upon gluten intake. The only current treatment available is lifelong …