Acyl-CoA: cholesterol acyltransferases (ACATs/SOATs): Enzymes with multiple sterols as substrates and as activators
Cholesterol is essential to the growth and viability of cells. The metabolites of cholesterol
include: steroids, oxysterols, and bile acids, all of which play important physiological …
include: steroids, oxysterols, and bile acids, all of which play important physiological …
Evolutionary insights into RNA trans-splicing in vertebrates
Q Lei, C Li, Z Zuo, C Huang, H Cheng… - Genome biology and …, 2016 - academic.oup.com
Pre-RNA splicing is an essential step in generating mature mRNA. RNA trans-splicing
combines two separate pre-mRNA molecules to form a chimeric non-co-linear RNA, which …
combines two separate pre-mRNA molecules to form a chimeric non-co-linear RNA, which …
Exon circularization requires canonical splice signals
S Starke, I Jost, O Rossbach, T Schneider, S Schreiner… - Cell reports, 2015 - cell.com
Circular RNAs (circRNAs), an abundant class of noncoding RNAs in higher eukaryotes, are
generated from pre-mRNAs by circularization of adjacent exons. Using a set of 15 circRNAs …
generated from pre-mRNAs by circularization of adjacent exons. Using a set of 15 circRNAs …
Acyl-coenzyme A: Cholesterol Acyltransferase (ACAT) in cholesterol metabolism: From its discovery to clinical trials and the genomics era
The purification and cloning of the acyl-coenzyme A: cholesterol acyltransferase (ACAT)
enzymes and the sterol O-acyltransferase (SOAT) genes has opened new areas of interest …
enzymes and the sterol O-acyltransferase (SOAT) genes has opened new areas of interest …
Functions of noncoding sequences in mammalian genomes
LI Patrushev, TF Kovalenko - Biochemistry (Moscow), 2014 - Springer
Most of the mammalian genome consists of nucleotide sequences not coding for proteins.
Exons of genes make up only 3% of the human genome, while the significance of most other …
Exons of genes make up only 3% of the human genome, while the significance of most other …
Transcriptional-readthrough RNAs reflect the phenomenon of “a gene contains gene (s)” or “gene (s) within a gene” in the human genome, and thus are not chimeric …
Tens of thousands of chimeric RNAs, ie, RNAs with sequences of two genes, have been
identified in human cells. Most of them are formed by two neighboring genes on the same …
identified in human cells. Most of them are formed by two neighboring genes on the same …
Antibiotic resistomes in water supply reservoirs sediments of central China: Main biotic drivers and distribution pattern
K Zhang, K Li, R Xin, Y Han, Z Guo, W Zou… - … Science and Pollution …, 2022 - Springer
Water supply reservoirs form one of the critical drinking water resources. Their water quality
directly affects human health. However, reservoir sediments have not received adequate …
directly affects human health. However, reservoir sediments have not received adequate …
A conserved intronic U1 snRNP-binding sequence promotes trans-splicing in Drosophila
Unlike typical cis-splicing, trans-splicing joins exons from two separate transcripts to
produce chimeric mRNA and has been detected in most eukaryotes. Trans-splicing in …
produce chimeric mRNA and has been detected in most eukaryotes. Trans-splicing in …
It is imperative to establish a pellucid definition of chimeric RNA and to clear up a lot of confusion in the relevant research
C Yuan, Y Han, L Zellmer, W Yang, Z Guan… - International Journal of …, 2017 - mdpi.com
There have been tens of thousands of RNAs deposited in different databases that contain
sequences of two genes and are coined chimeric RNAs, or chimeras. However,“chimeric …
sequences of two genes and are coined chimeric RNAs, or chimeras. However,“chimeric …
Trans-spliced long non-coding RNA: an emerging regulator of pluripotency
CY Yu, CY Chuang, HC Kuo - Cellular and Molecular Life Sciences, 2018 - Springer
With dual capacities for unlimited self-renewal and pluripotent differentiation, pluripotent
stem cells (PSCs) give rise to many cell types in our body and PSC culture systems provide …
stem cells (PSCs) give rise to many cell types in our body and PSC culture systems provide …