IL-17 and IL-17-producing cells in protection versus pathology

KHG Mills - Nature Reviews Immunology, 2023 - nature.com
IL-17 cytokine family members have diverse biological functions, promoting protective
immunity against many pathogens but also driving inflammatory pathology during infection …

Cutaneous leishmaniasis: immune responses in protection and pathogenesis

P Scott, FO Novais - Nature Reviews Immunology, 2016 - nature.com
Cutaneous leishmaniasis is a major public health problem and causes a range of diseases
from self-healing infections to chronic disfiguring disease. Currently, there is no vaccine for …

Pro-and anti-inflammatory cytokines in cutaneous leishmaniasis: a review

N Maspi, A Abdoli, F Ghaffarifar - Pathogens and global health, 2016 - Taylor & Francis
Cutaneous leishmaniasis (CL) is caused by different species of the genus Leishmania. Pro-
and anti-inflammatory cytokines play different roles in resistance/susceptibility and the …

Possibilities and challenges for developing a successful vaccine for leishmaniasis

S Srivastava, P Shankar, J Mishra, S Singh - Parasites & vectors, 2016 - Springer
Leishmaniasis is a vector-borne disease caused by different species of protozoan parasites
of the genus Leishmania. It is a major health problem yet neglected tropical diseases, with …

Biology of interleukin-17 and its pathophysiological significance in sepsis

Y Ge, M Huang, Y Yao - Frontiers in immunology, 2020 - frontiersin.org
The interleukin (IL)-17 family includes six structure-related cytokines (A–F). To date, majority
of studies have focused on IL-17A. IL-17A plays a pivotal role in various infectious diseases …

The Role of Nitric Oxide and Reactive Oxygen Species in the Killing of Leishmania braziliensis by Monocytes from Patients with Cutaneous Leishmaniasis

PP Carneiro, J Conceição, M Macedo, V Magalhães… - PloS one, 2016 - journals.plos.org
Human cutaneous leishmaniasis (CL) caused by Leishmania braziliensis, presents an
exaggerated Th1 response that is associated with ulcer development. Macrophages are the …

Host immune responses to the itch mite, Sarcoptes scabiei, in humans

SA Bhat, KE Mounsey, X Liu, SF Walton - Parasites & vectors, 2017 - Springer
Scabies is a parasitic disease due to infestation of skin by the burrowing mite Sarcoptes
scabiei. Scabies is a major public health problem and endemic in resource poor …

The equivocal role of Th17 cells and neutrophils on immunopathogenesis of leishmaniasis

SC Gonçalves-de-Albuquerque… - Frontiers in …, 2017 - frontiersin.org
Advances in the understanding of leishmaniasis progression indicate that cellular
interactions more complex than the Th1/Th2 paradigm define the course of infection. Th17 …

Variable gene expression and parasite load predict treatment outcome in cutaneous leishmaniasis

CF Amorim, FO Novais, BT Nguyen, AM Misic… - Science translational …, 2019 - science.org
Patients infected with Leishmania braziliensis develop chronic lesions that often fail to
respond to treatment with antiparasite drugs. To determine whether genes whose …

The balancing act: Immunology of leishmaniosis

AJ Toepp, CA Petersen - Research in veterinary science, 2020 - Elsevier
Immune control of Leishmania infantum, the causative agent of most canine leishmaniosis
(CanL), requires a balancing act between inflammatory and regulatory responses. This …