Mitochondrial fusion and fission tailors the mitochondrial shape to changes in cellular
homeostasis. Players of this process are the mitofusins, which regulate fusion of the outer …

Dynamin mediates fission of vesicles from the plasma membrane during endocytosis.
Typically, dynamin is recruited from the cytosol to endocytic sites, requiring seconds to tens …

In the past decade, compelling evidence has accumulated that highlights the role of various
subcellular structures in human disease conditions. Dysregulation of these structures greatly …

Metabolic reactions in living cells are limited by diffusion of reagents in the cytoplasm. Any
attempt to quantify the kinetics of biochemical reactions in the cytosol should be preceded by …

The complexity of the cellular medium can affect proteins' properties, and, therefore, in-cell
characterization of proteins is essential. We explored the stability and conformation of the …

Diffusive motion accompanies many physical and biological processes. The Stokes–
Sutherland–Einstein relation for the translational diffusion coefficient, DT, agrees with …

Drp1 is a central player in mitochondrial fission and is recruited to mitochondria by Mff and
MIEFs (MIEF1 and MIEF2), but little is known about how its assembly state affects Drp1 …

Green fluorescent protein (GFP)-tagging is the prevalent strategy to monitor protein
dynamics in living cells. However, the consequences of appending the bulky GFP moiety to …

Mitochondrial fission is a critical cellular event to maintain organelle function. This multistep
process is initiated by the enhanced recruitment and oligomerization of dynamin-related …

Bevacizumab is a biological drug that is now extensively studied in clinics against various
types of cancer. Although bevacizumab's action is preferably extracellular, there are reports …