Cellular senescence is a state of stable cell cycle arrest that is known to be elicited in
response to different stresses or forms of damage. Senescence limits the replication of old …

The global prevalence rate for congenital hydrocephalus (CH) is approximately one out of
every five hundred births with multifaceted predisposing factors at play. Genetic influences …

Biosynthesis of macromolecules requires precursors such as sugars or amino acids,
originating from exogenous/dietary sources, reutilization/salvage of degraded molecules, or …

Dietary adaptation is a major feature of phenotypic and ecological diversification, yet the
genetic basis of dietary shifts is poorly understood. Among mammals, Neotropical leaf …

O-Fucosylation plays crucial roles in various essential biological events. Alongside the well-
established O-fucosylation of epidermal growth factor-like repeats by protein O …

Many extracellular matrix (ECM) associated proteins that influence ECM properties have
Thrombospondin type 1 repeats (TSRs) which are modified with O-linked fucose. The O …

ADAMTSL2 mutations cause an autosomal recessive connective tissue disorder,
geleophysic dysplasia 1 (GPHYSD1), which is characterized by short stature, small hands …

The extracellular matrix (ECM) is central to the physiology of animal tissues, through its
multifaceted roles in tissue structure, mechanical properties, and cell interactions, and by its …

Breast cancer (bc) is the second most common type of human malignancies with highest
morbidity and mortality in the female population. Therefore, it is essential to develop novel …

Peters plus syndrome, characterized by defects in eye and skeletal development with
isolated cases of ventriculomegaly/hydrocephalus, is caused by mutations in the β3 …