Membrane lipids interact with proteins in a variety of ways, ranging from providing a stable
membrane environment for proteins to being embedded in to detailed roles in complicated …

After cell entry, human immunodeficiency virus type 1 (HIV-1) replication involves reverse
transcription of the RNA genome, nuclear import of the subviral complex without nuclear …

Summary Human immunodeficiency virus (HIV-1) remains a major health threat. Viral capsid
uncoating and nuclear import of the viral genome are critical for productive infection. The …

Oral antiretroviral agents provide life-saving treatments for millions of people living with HIV,
and can prevent new infections via pre-exposure prophylaxis,,,–. However, some people …

HIV-1 capsid core disassembly (uncoating) must occur before integration of viral genomic
DNA into the host chromosomes, yet remarkably, the timing and cellular location of …

We recently reported that HIV-1 cores that retained> 94% of their capsid (CA) protein
entered the nucleus and disassembled (uncoated) near their integration site< 1.5 h before …

HIV-1 Nef, a protein important for the development of AIDS, has well-characterized effects on
host membrane trafficking and receptor downregulation. By an unidentified mechanism, Nef …

INTRODUCTION Reverse transcription and integration are the signature events of retrovirus
replication. Reverse transcription creates a double-stranded DNA (dsDNA) copy of the …

Retroviral capsid proteins are conserved structurally but assemble into different
morphologies. The mature human immunodeficiency virus-1 (HIV-1) capsid is best …

HIV-1 replication commences inside the cone-shaped viral capsid, but timing, localization,
and mechanism of uncoating are under debate. We adapted a strategy to visualize …