Cannabinoids, Phenolics, Terpenes and Alkaloids of Cannabis

MM Radwan, S Chandra, S Gul, MA ElSohly - Molecules, 2021 - mdpi.com
Cannabis sativa is one of the oldest medicinal plants in the world. It was introduced into
western medicine during the early 19th century. It contains a complex mixture of secondary …

Goods and bads of the endocannabinoid system as a therapeutic target: Lessons learned after 30 years

M Maccarrone, V Di Marzo, J Gertsch, U Grether… - Pharmacological …, 2023 - ASPET
The cannabis derivative marijuana is the most widely used recreational drug in the Western
world and is consumed by an estimated 83 million individuals (∼ 3% of the world …

Cannabinoid receptors and the endocannabinoid system: signaling and function in the central nervous system

S Zou, U Kumar - International journal of molecular sciences, 2018 - mdpi.com
The biological effects of cannabinoids, the major constituents of the ancient medicinal plant
Cannabis sativa (marijuana) are mediated by two members of the G-protein coupled …

Review of delta‐8‐tetrahydrocannabinol (Δ8‐THC): Comparative pharmacology with Δ9‐THC

M Tagen, LE Klumpers - British journal of pharmacology, 2022 - Wiley Online Library
The use of the intoxicating cannabinoid delta‐8‐tetrahydrocannabinol (Δ8‐THC) has grown
rapidly over the last several years. There have been dozens of Δ8‐THC studies dating back …

Cannabinoids, the endocannabinoid system, and pain: a review of preclinical studies

DP Finn, S Haroutounian, AG Hohmann, E Krane… - Pain, 2021 - journals.lww.com
This narrative review represents an output from the International Association for the Study of
Pain's global task force on the use of cannabis, cannabinoids, and cannabis-based …

Cannabidiol adverse effects and toxicity

MA Huestis, R Solimini, S Pichini… - Current …, 2019 - ingentaconnect.com
Background: Currently, there is a great interest in the potential medical use of cannabidiol
(CBD), a non-intoxicating cannabinoid. Productive pharmacological research on CBD …

Structural and chemical biology of terpenoid cyclases

DW Christianson - Chemical reviews, 2017 - ACS Publications
The year 2017 marks the twentieth anniversary of terpenoid cyclase structural biology: a trio
of terpenoid cyclase structures reported together in 1997 were the first to set the foundation …

New approaches and challenges to targeting the endocannabinoid system

V Di Marzo - Nature Reviews Drug Discovery, 2018 - nature.com
The endocannabinoid signalling system was discovered because receptors in this system
are the targets of compounds present in psychotropic preparations of Cannabis sativa. The …

The cannabis terpenes

SR Sommano, C Chittasupho, W Ruksiriwanich… - Molecules, 2020 - mdpi.com
Terpenes are the primary constituents of essential oils and are responsible for the aroma
characteristics of cannabis. Together with the cannabinoids, terpenes illustrate synergic …

[HTML][HTML] The case for the entourage effect and conventional breeding of clinical cannabis: no “strain,” no gain

EB Russo - Frontiers in plant science, 2019 - frontiersin.org
The topic of Cannabis curries controversy in every sphere of influence, whether politics,
pharmacology, applied therapeutics or even botanical taxonomy. Debate as to the …