Hierarchical nanomaterials assembled from peptoids and other sequence-defined synthetic polymers

Z Li, B Cai, W Yang, CL Chen - Chemical Reviews, 2021 - ACS Publications
In nature, the self-assembly of sequence-specific biopolymers into hierarchical structures
plays an essential role in the construction of functional biomaterials. To develop synthetic …

The diverse world of foldamers: endless possibilities of self-assembly

S Rinaldi - Molecules, 2020 - mdpi.com
Different classes of foldamers, which are synthetic oligomers that adopt well-defined
conformations in solution, have been the subject of extensive studies devoted to the …

Single-molecule polypeptoid stretching reveals the effects of charge sequence on chain conformation

HP Truong, S Mengel, B Yu, RA Segalman… - …, 2023 - ACS Publications
Elucidating the effect of charge sequence on polyelectrolyte conformation is important to
understanding many biophysical processes and advancing the design of sequence-defined …

Biomolecular assemblies: moving from observation to predictive design

CJ Wilson, AS Bommarius, JA Champion… - Chemical …, 2018 - ACS Publications
Biomolecular assembly is a key driving force in nearly all life processes, providing structure,
information storage, and communication within cells and at the whole organism level. These …

Supramolecular Nanosheets Assembled from Poly(ethylene glycol)-b-poly(N-(2-phenylethyl)glycine) Diblock Copolymer Containing Crystallizable Hydrophobic …

Y Wei, J Tian, Z Zhang, C Zhu, J Sun, Z Li - Macromolecules, 2019 - ACS Publications
Supramolecular two-dimensional (2D) nanomaterials from block copolymers have received
great interest for their unique structure and properties. Here, we report the formation of …

Structural elucidation of a polypeptoid chain in a crystalline lattice reveals key morphology-directing role of the N-terminus

T Yu, X Luo, D Prendergast, GL Butterfoss, B Rad… - ACS …, 2023 - ACS Publications
The ability to engineer synthetic polymers with the same structural precision as
biomacromolecules is crucial to enable the de novo design of robust nanomaterials with …

Conformations of peptoids in nanosheets result from the interplay of backbone energetics and intermolecular interactions

JR Edison, RK Spencer, GL Butterfoss… - Proceedings of the …, 2018 - National Acad Sciences
The conformations adopted by the molecular constituents of a supramolecular assembly
influence its large-scale order. At the same time, the interactions made in assemblies by …

Control over conformational landscapes of polypeptoids by monomer sequence patterning

AJ DeStefano, SD Mengel, MW Bates, S Jiao… - …, 2024 - ACS Publications
The ability to program chain conformation and structure through control over the monomer
sequence of synthetic polymers has broad implications for next-generation material design …

2D Liquid-Crystallization-Driven Self-Assembly of Rod–Coil Block Copolymers: Living Growth and Self-Similarity

C Zhang, J Lin, L Wang, L Gao - The Journal of Physical Chemistry …, 2022 - ACS Publications
Liquid-crystallization-driven self-assembly (LCDSA) is an emerging methodology, which has
been employed to construct controllable 1D nanostructures. However, 2D nanostructures via …

Engineering the atomic structure of sequence-defined peptoid polymers and their assemblies

S Xuan, RN Zuckermann - Polymer, 2020 - Elsevier
Peptoids are a family of sequence-defined, non-natural biomimetic polymers which show
excellent properties including good chemical and enzymatic stability and high structural …