The innate immune response provides the first line of defense against invading pathogens,
and immune disorders cause a variety of diseases. The fruit fly Drosophila melanogaster …

The gastrointestinal tract has recently come to the forefront of multiple research fields. It is
now recognized as a major source of signals modulating food intake, insulin secretion and …

Cancer is a multistep disease driven by the activation of specific oncogenic pathways
concomitantly with the loss of function of tumor suppressor genes that act as sentinels to …

Inflammation underlies many chronic and degenerative diseases, but it also mitigates
infections, clears damaged cells and initiates tissue repair. Many of the mechanisms that link …

The licensed drug rapamycin has potential to be repurposed for geroprotection. A key
challenge is to avoid adverse side effects from continuous dosing. Here we show that …

Programmed cell death (PCD) pathways, including apoptosis and regulated necrosis, are
required for normal cell turnover and tissue homeostasis. Mis-regulation of PCD is …

Studies of the adult Drosophila midgut have led to many insights in our understanding of cell-
type diversity, stem cell regeneration, tissue homeostasis, and cell fate decision. Advances …

The skin is a squamous epithelium that is continuously renewed by a population of basal
layer stem/progenitor cells and can heal wounds. Here, we show that the transcription …

Interactions between commensals and the host impact the metabolic and immune status of
metazoans. Their deregulation is associated with age-related pathologies like chronic …

Intestinal homeostasis is achieved, in part, by the integration of a complex set of
mechanisms that eliminate pathogens and tolerate the indigenous microbiota. Drosophila …