Drug delivery challenges in brain disorders across the blood–brain barrier: novel methods and future considerations for improved therapy

A Achar, R Myers, C Ghosh - Biomedicines, 2021 - mdpi.com
Due to the physiological and structural properties of the blood–brain barrier (BBB), the
delivery of drugs to the brain poses a unique challenge in patients with central nervous …

Advanced Temporally‐Spatially Precise Technologies for On‐Demand Neurological Disorder Intervention

X Chen, Y Gong, W Chen - Advanced Science, 2023 - Wiley Online Library
Temporal‐spatial precision has attracted increasing attention for the clinical intervention of
neurological disorders (NDs) to mitigate adverse effects of traditional treatments and …

A 3D flexible neural interface based on a microfluidic interconnection cable capable of chemical delivery

YN Kang, N Chou, JW Jang, HK Choe… - Microsystems & …, 2021 - nature.com
The demand for multifunctional neural interfaces has grown due to the need to provide a
better understanding of biological mechanisms related to neurological diseases and neural …

Behavioral, neural and ultrastructural alterations in a graded-dose 6-OHDA mouse model of early-stage Parkinson's disease

A Slézia, P Hegedüs, E Rusina, K Lengyel, N Solari… - Scientific Reports, 2023 - nature.com
Studying animal models furthers our understanding of Parkinson's disease (PD)
pathophysiology by providing tools to investigate detailed molecular, cellular and circuit …

Intrahippocampal Supramolecular Assemblies Directed Bioorthogonal Liberation of Neurotransmitters to Suppress Seizures in Freely Moving Mice

C Wu, J Xie, Q Yao, Y Song, G Yang, J Zhao… - Advanced …, 2024 - Wiley Online Library
The precise delivery of anti‐seizure medications (ASM) to epileptic loci remains the major
challenge to treat epilepsy without causing adverse drug reactions. The unprovoked nature …

Geraniol Ameliorates Pentylenetetrazol-Induced Epilepsy, Neuroinflammation, and Oxidative Stress via Modulating the GABAergic Tract: In vitro and in vivo studies

NS Younis, MM Almostafa… - … Design, Development and …, 2024 - Taylor & Francis
Introduction Geraniol (Ger), a monoterpene, is a common constituent of several essential
oils. This study explored the anticonvulsant effect of Ger in-vitro using nerve growth factor …

[HTML][HTML] Pharmacokinetics and tissue distribution of vigabatrin enantiomers in rats

Q Zheng, S He, SL Xu, MD Ma, M Fan, JF Ge - Saudi Pharmaceutical …, 2024 - Elsevier
Purpose To investigate the pharmacokinetics and tissue distribution of VGB racemate and its
single enantiomers, and explore the potential of clinic development for single enantiomer S …

A Revolutionary Approach for Combating Efflux Transporter-mediated Resistant Epilepsy: Advanced Drug Delivery Systems

M Tonk, I Singh, RJ Sharma… - Current Pharmaceutical …, 2025 - benthamdirect.com
Epilepsy is a persistent neurological condition that affects 60 million individuals globally,
with recurrent spontaneous seizures affecting 80% of patients. Antiepileptic drugs (AEDs) …

Anesthesia and analgesia for experimental craniotomy in mice and rats: a systematic scoping review comparing the years 2009 and 2019

H King, M Reiber, V Philippi, H Stirling… - Frontiers in …, 2023 - frontiersin.org
Experimental craniotomies are a common surgical procedure in neuroscience. Because
inadequate analgesia appears to be a problem in animal-based research, we conducted …

Polymers/PEDOT Derivatives for Bioelectronics

MJ Donahue, CM Proctor, X Strakosas - 2020 - books.rsc.org
The evolution of polymer materials over the past few decades has brought significant
advancement to next-generation organic electronic devices. These devices range from …