Harnessing the patient's immune system to control a tumor is a proven avenue for cancer
therapy. T cell therapies as well as therapeutic vaccines, which target specific antigens of …

Alternative polyadenylation (APA) enables a gene to generate multiple transcripts with
different 3′ ends, which is dynamic across different cell types or conditions. Many …

Transcriptional dysregulation is a recurring pathogenic hallmark and an emerging
therapeutic vulnerability in ovarian cancer. Here, we demonstrated that ovarian cancer …

Dystrophinopathy is caused by alterations in DMD. Approximately 1% of patients remain
genetically undiagnosed, because intronic variations are not detected by standard methods …

Functional interpretation of disease-associated non-coding variants remains a significant
challenge in the post-GWAS era. Our recent study has identified 3′ UTR alternative …

Genetic mutations arising from various internal and external factors drive cells to become
cancerous. Cancerous cells undergo numerous changes, including metabolic …

Recent emerging evidence has shown that readthrough transcripts (RTs), including
polycistronic mRNAs, are also transcribed in eukaryotes. However, the post-transcriptional …

Nucleic acid nanotechnologies based on toehold-mediated strand displacement are ideally
suited for single-nucleotide variations (SNVs) detection. But only a limited number of means …

Cryptic transcription initiation has been previously linked to activation of oncogenic
transcripts. However, the prevalence and impact of cryptic antisense transcription from the …

The expression of eukaryotic genes relies on the precise 3'-terminal cleavage and
polyadenylation of newly synthesized pre-mRNA transcripts. Defects in these processes …