Once damaged, articular cartilage has a limited potential to repair. Clinically, a repair tissue
is formed, yet, it is often mechanically inferior fibrocartilage. The use of monolayer expanded …

MicroRNAs are small double-stranded RNAs, which negatively regulate gene expression
and have been shown to have key roles in both chondrocyte development and cartilage …

OBJECTIVES: Osteoarthritis (OA) is the most common joint disease throughout the world.
Exosomes derived from miR-140-5p-overexpressing synovial mesenchymal stem cells …

Research into the molecular genetics of osteoarthritis (OA) has been substantially bolstered
in the past few years by the implementation of powerful genome-wide scans that have …

MicroRNAs are small noncoding RNAs that can bind to the target sites in the 3'‐untranslated
region of messenger RNA to regulate posttranscriptional gene expression. Increasing …

Highlights•ACI is the gold standard cell therapy for cartilage defect repair.•MSCs are
promising substitutes for chondrocytes in ACI-like procedures.•Intra-articular MSC delivery …

Exosomes are a subset of small, membrane-bound extracellular vesicles that are important
for communication among cells. They originate from the cell membrane during endocytic …

MicroRNAs have been shown to function in cartilage development and homeostasis, as well
as in progression of osteoarthritis. The objective of the current study was to identify …

Osteoarthritis (OA) is the most common degenerative joint disease. One of the main
pathogenic factors of OA is thought to be inflammation. Other factors associated with OA are …

MicroRNAs are small non-coding RNAs that play important roles in many cellular processes
including proliferation, metabolism and differentiation. They function by binding to specific …