Vancomycin and teicoplanin are the two glycopeptide antibiotics that are used clinically, and
the emergence of resistance to them poses a serious threat to human health. Some …

Many biologically active small‐molecule natural products produced by microorganisms
derive their activities from sugar substituents. Changing the structures of these sugars can …

The multigene family of enzymes known as glycosyltransferases or popularly known as GTs
catalyze the addition of carbohydrate moiety to a variety of synthetic as well as natural …

Books dealing with the mechanisms of enzymatic reactions were written a generation ago.
They included volumes entitled Bioorganic Mechanisms, I and II by TC Bruice and SJ …

Covering: the literature up to April 2005The focus of this review is to highlight the structure,
bioactivity and biosynthesis of naturally occurring aryl-C-glycosides. General synthetic …

Covering: up to the end of May 2011 Glyco (randomization/diversification) is a term that
encompasses strategies to diversify a core drug scaffold via enzymatic glycosylation to …

Plant family 1 UDP-dependent glycosyltransferases (UGTs) catalyze the glycosylation of a
plethora of bioactive natural products. In Arabidopsis thaliana, 120 UGT encoding genes …

The enzymes involved in the biosynthesis of carbohydrates and the attachment of sugar
units to biological acceptor molecules catalyse an array of chemical transformations and …

Microbial natural products of both polyketide and nonribosomal peptide origin have been
and continue to be important therapeutic agents as antibiotics, immunosupressants, and …

Glycosylated natural products are reliable platforms for the development of many front-line
drugs, yet our understanding of the relationship between attached sugars and biological …