Opioid use disorder (OUD) is a chronic relapsing disorder that, whilst initially driven by
activation of brain reward neurocircuits, increasingly engages anti-reward neurocircuits that …

Opioid use during pregnancy impacts the health and well‐being of two generations: the
pregnant person and the child. The factors that increase risk for opioid use in the adult, as …

Pharmacogenomics is the study of genetic variants that impact drug effects through changes
in a drug's pharmacokinetics and pharmacodynamics. Pharmacogenomics is being …

Pain is a common symptom that can be complex to treat. Analgesic medications are the
mainstay treatment, but there is wide interindividual variability in analgesic response and …

Postoperative nausea and vomiting (PONV) remains one of the most common adverse
effects of anesthesia, affecting up to 80% of high-risk patients within 24 hours after surgery …

Despite the various different candidate genetic polymorphisms of potential clinical
relevance, there is not enough understanding of the inter‑individual variability in analgesic …

Background Opioid use has more than doubled over recent decades, and Denmark
occupies fifth place in the global ranking. These increases have been partly attributed to the …

An urgent need exists to better understand the transition from short-term opioid use to
unintended prolonged opioid use (UPOU). The purpose of this work is to propose a …

Background As pain is often a comorbid condition, many patients use opioid analgesics in
combination with several other drugs. This implies a generally increased risk of drug …

Methods: An anonymous online survey was distributed by e-mail to the orthopaedic
societies of all 50 states and several large private practices to assess practicing orthopaedic …