Neutrophils are predominant immune cells that protect the human body against infections by
deploying sophisticated antimicrobial strategies including phagocytosis of bacteria and …

Reactive oxygen species (ROS) have been shown to be toxic but also function as signalling
molecules. This biological paradox underlies mechanisms that are important for the integrity …

Maintenance of the cellular redox balance is crucial for cell survival. An increase in reactive
oxygen, nitrogen, or chlorine species can lead to oxidative stress conditions, potentially …

Sodium hypochlorite (NaOCl) and its active ingredient, hypochlorous acid (HOCl), are the
most commonly used chlorine-based disinfectants. HOCl is a fast-acting and potent …

Exposure of cells to sublethal oxidative stress results in the modulation of various signaling
pathways. Oxidants can activate and inactivate transcription factors, membrane channels …

Zinc fingers (ZFs) are among the most structurally diverse protein domains. They interact
with nucleic acids, other proteins and lipids to facilitate a multitude of biological processes …

Oxidants are produced as a by-product of aerobic metabolism, and organisms ranging from
prokaryotes to mammals have evolved with an elaborate and redundant complement of …

The generation of reactive oxygen species (ROS) is inevitably linked to life. However, the
precise role of ROS in signalling and specific targets is largely unknown. We perform a …

Some of the most challenging stress conditions that organisms encounter during their
lifetime involve the transient accumulation of reactive oxygen and chlorine species …

Hypochlorous acid (HOCl), the active ingredient of household bleach, is the most common
disinfectant in medical, industrial, and domestic use and plays an important role in microbial …