Targeted therapeutics underwent a revolution with the entry of monoclonal antibodies in the
medical toolkit. Oligonucleotide aptamers form another family of target agents that have …

Many clinical trials using gene therapy have shown significant therapeutic benefits and
exceptional safety records. Increasing evidence is verifying the long sought-after promise …

RNA–protein interactions underlie a wide range of cellular processes. Improved methods
are needed to systematically map RNA–protein interactions in living cells in an unbiased …

APEX is an engineered peroxidase that catalyzes the oxidation of a wide range of
substrates, facilitating its use in a variety of applications from subcellular staining for electron …

Transcriptome-wide identification of RNA-binding proteins (RBPs) is a prerequisite for
understanding the posttranscriptional gene regulation networks. However, proteomic …

Amyotrophic lateral sclerosis and frontotemporal dementia patients with a hexanucleotide
repeat expansion in C9ORF72 (C9-HRE) accumulate poly-GR and poly-PR aggregates. The …

Long noncoding RNAs (lncRNAs) are large RNA transcripts that do not code for proteins but
exert their effects in the form of RNA. To date many thousands of lncRNAs have been …

The innate immune response must be terminated in a timely manner at the late stage of
infection to prevent unwanted inflammation. The role of m 6 A-modified RNAs and their …

Short Tandem Repeats (STRs) are frequent entities in many transcripts, however, in some
cases, pathological events occur when a critical repeat length is reached. This phenomenon …

Transcribed CGG repeat expansions cause neurodegeneration in Fragile X‐associated
tremor/ataxia syndrome (FXTAS). CGG repeat RNAs sequester RNA‐binding proteins …