Pelvic Inflammatory Disease Due to Neisseria gonorrhoeae and Chlamydia trachomatis: Immune Evasion Mechanisms and Pathogenic Disease Pathways

T Darville - The Journal of infectious diseases, 2021 - academic.oup.com
Pelvic inflammatory disease (PID) results from ascension of sexually transmitted pathogens
from the lower genital tract to the uterus and/or fallopian tubes in women, with potential …

Bacterial colonization of the female upper genital tract

A Peric, J Weiss, N Vulliemoz, D Baud… - International journal of …, 2019 - mdpi.com
Bacteria colonize most of the human body, and the female genital tract is not an exception.
While the existence of a vaginal microbiota has been well established, the upper genital …

Progress toward a gonococcal vaccine: the way forward

MW Russell, AE Jerse, SD Gray-Owen - Frontiers in immunology, 2019 - frontiersin.org
The concept of immunizing against gonorrhea has received renewed interest because of the
recent emergence of strains of Neisseria gonorrhoeae that are resistant to most currently …

Gonococcal pelvic inflammatory disease: placing mechanistic insights into the context of clinical and epidemiological observations

SX Xu, SD Gray-Owen - The Journal of Infectious Diseases, 2021 - academic.oup.com
While infection by Neisseria gonorrhoeae is often asymptomatic in women, undetected
infections can ascend into the upper genital tract to elicit an inflammatory response that …

Tissue Models for Neisseria gonorrhoeae Research—From 2D to 3D

M Heydarian, E Rühl, R Rawal… - Frontiers in Cellular and …, 2022 - frontiersin.org
Neisseria gonorrhoeae is a human-specific pathogen that causes gonorrhea, the second
most common sexually transmitted infection worldwide. Disease progression, drug …

Triple co-culture and perfusion bioreactor for studying the interaction between Neisseria gonorrhoeae and neutrophils: A novel 3D tissue model for bacterial infection …

M Heydarian, M Schweinlin… - Journal of Tissue …, 2021 - journals.sagepub.com
Gonorrhea, a sexually transmitted disease caused by the bacteria Neisseria gonorrhoeae, is
characterized by a large number of neutrophils recruited to the site of infection. Therefore …

Unveiling the immune dynamics of Neisseria persistent oral colonization

M Alles, M Gunasena, T Zia, A D'Mello… - Infection and …, 2024 - Am Soc Microbiol
Commensal bacteria are crucial in maintaining host physiological homeostasis, immune
system development, and protection against pathogens. Despite their significance, the …

Lactobacillus crispatus and its enolase and glutamine synthetase influence interactions between Neisseria gonorrhoeae and human epithelial cells

J Płaczkiewicz, P Chmiel, E Malinowska, P Bącal… - journal of …, 2020 - Springer
Neisseria gonorrhoeae, an obligatory human pathogen causes the sexually transmitted
disease gonorrhea, which remains a global health problem. N. gonorrhoeae primarily infects …

Vertebrate and Invertebrate Animal and New In Vitro Models for Studying Neisseria Biology

MM Girgis, M Christodoulides - Pathogens, 2023 - mdpi.com
The history of Neisseria research has involved the use of a wide variety of vertebrate and
invertebrate animal models, from insects to humans. In this review, we itemise these models …

IL-17C is a driver of damaging inflammation during Neisseria gonorrhoeae infection of human Fallopian tube

EM Garcia, JD Lenz, RE Schaub, KT Hackett… - Nature …, 2024 - nature.com
The human pathogen Neisseria gonorrhoeae ascends into the upper female reproductive
tract to cause damaging inflammation within the Fallopian tubes and pelvic inflammatory …