The basal ganglia are a highly interconnected set of subcortical nuclei and major atrophy in
one or more regions may have major effects on other regions of the brain. Therefore, the …

Huntington's disease (HD) is an autosomal dominant progressive neurodegenerative
disorder that prominently affects the basal ganglia, leading to affective, cognitive, behavioral …

The present study analyzes the relationship between cortical and subcortical brain volumes
in patients with Huntington's disease. The brains of seven patients with a clinical diagnosis …

Prior studies suggest differences exist among striatal projection neuron types in their
vulnerability to Huntington's disease (HD). In the present study, we immunolabeled the fibers …

Expanded polyglutamine (polyQ) proteins in Huntington's disease (HD) as well as other
polyQ disorders are known to elicit a variety of intracellular toxicities, but it remains unclear …

This paper reviews the major anatomical and chemical features of the various types of
interneurons in the human striatum, as detected by immunostaining procedures applied to …

Immunohistochemistry and single-cell RT-PCR were used to characterize the localization of
huntingtin and/or its mRNA in the major types of striatal neurons and in corticostriatal …

Huntington's disease (HD) is a hereditary progressive neurodegenerative disorder caused
by a CAG repeat expansion in the gene coding for the protein huntingtin, resulting in a …

The different types of striatal neuron show a range of vulnerabilities to a variety of insults.
This can be clearly seen in Huntington's disease where a well mapped pattern of …

Although dystonia represents a major source of motor disability in Huntington's disease
(HD), its pathophysiology remains unknown. Because recent animal studies indicate that …