Macrophages are essential for skeletal muscle homeostasis, but how their dysregulation
contributes to the development of fibrosis in muscle disease remains unclear. Here, we used …

Skeletal muscle regeneration is a complex process involving the generation of new
myofibers after trauma, competitive physical activity, or disease. In this context, adult skeletal …

Skeletal muscle is essential for body physical activity, energy metabolism, and temperature
maintenance. It has excellent capabilities to maintain homeostasis and to regenerate after …

Dysregulated inflammation involving innate immune cells, particularly of the monocyte/
macrophage lineage, is a key contributor to the pathogenesis of Duchenne muscular …

We performed scRNA-seq/snATAC-seq of skeletal muscles post sciatic nerve transection to
delineate cell type-specific patterns of gene expression/chromatin accessibility at different …

Spinal muscular atrophy (SMA) is a genetic neuromuscular disorder caused by the reduction
of survival of motor neuron (SMN) protein levels. Although three SMN-augmentation …

Duchenne muscular dystrophy (DMD) is caused by an out-of-frame mutation in the DMD
gene that results in the absence of a functional dystrophin protein, leading to a devastating …

Skeletal muscle regeneration relies on the intricate interplay of various cell populations
within the muscle niche—an environment crucial for regulating the behavior of muscle stem …

Mutations in the DMD gene lead to Duchenne muscular dystrophy (DMD), a severe
neuromuscular disorder affecting young boys as they acquire motor functions. DMD is …

Mutations in the DMD gene lead to Duchenne muscular dystrophy, a severe X-linked
neuromuscular disorder that manifests itself as young boys acquire motor functions. DMD is …