Osteocytes, the most abundant and long-lived cells in bone, are the master regulators of
bone remodeling. In addition to their functions in endocrine regulation and calcium and …

Bone tissue has a remarkable ability to regenerate and heal itself. However, large bone
defects and complex fractures still present a significant challenge to the medical community …

The development of tissue engineering in the field of orthopaedic surgery is now booming.
Two fields of research in particular are emerging: the association of osteo-inductive factors …

This second edition of the Bone Mechanics Handbook summarizes the current
understanding of bone mechanics with comprehensive coverage of the histology …

Poor cell adhesion to orthopaedic and dental implants may result in implant failure. Cellular
adhesion to biomaterial surfaces primarily is mediated by integrins, which act as signal …

Contrary to the commonly held misconception, bone is a relatively dynamic organ that
undergoes significant turnover as compared to other organs in the body. This review details …

Osteoblast cell adhesion is the initial step of early osseointegration responding to bone
material implants. Enhancing the osteoblastic cell adhesion has become one of the prime …

We previously reported a transgenic mouse model expressing herpesvirus thymidine kinase
(TK) gene under the control of a 2.3-kilobase fragment of the rat collagen α1 type I promoter …

Bone tissue has the capacity to adapt to its functional environment such that its morphology
is “optimized” for the mechanical demand. The adaptive nature of the skeleton poses an …

Better materials are needed to promote bone growth. For this reason, the present study
created nanometer crystalline hydroxyapatite (HA) and amorphous calcium phosphate …