Non-alcoholic fatty liver disease (NAFLD) has emerged pandemically across the globe and
particularly affects patients with obesity and type 2 diabetes. NAFLD is a complex systemic …

Non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH) has become the leading
cause of liver disease worldwide. NASH, an advanced form of NAFL, can be progressive …

In response to a wide range of stimulations, host cells activate pyroptosis, a kind of
inflammatory cell death which is provoked by the cytosolic sensing of danger signals and …

Pancreatic and lung cancers frequently develop resistance to chemotherapy-induced cell
apoptosis during the treatment, indicating that targeting nonapoptotic-related pathways …

Background & Aims Non-alcoholic steatohepatitis (NASH) is associated with the
dysregulation of lipid metabolism and hepatic inflammation, though the underlying …

Inflammation is a defense mechanism that can protect the host against microbe invasion. A
proper inflammatory response can maintain homeostasis, but continuous inflammation can …

Inflammasomes are multiprotein complexes that can sense danger signals and activate
caspase-1 to mediate pro-inflammatory cytokines release and pyroptotic cell death. There …

Cholesterol is a crucial component of membrane bilayers by regulating their structural and
functional properties. Cholesterol traffics to different cellular compartments including …

Alcoholic liver disease (ALD) is a global public health challenge due to the high incidence
and lack of effective therapeutics. Evidence from animal studies and ALD patients has …

Nonalcoholic fatty liver disease (NAFLD) is characterised by hepatic steatosis, inflammation,
and insulin resistance. The role of long noncoding RNA (lncRNA)-regulated pyroptosis in …