Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in …
P Godoy, NJ Hewitt, U Albrecht, ME Andersen… - Archives of …, 2013 - Springer
This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …
[HTML][HTML] Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing
U Marx, TB Andersson, A Bahinski, M Beilmann… - Altex, 2016 - ncbi.nlm.nih.gov
The recent advent of microphysiological systems–microfluidic biomimetic devices that aspire
to emulate the biology of human tissues, organs and circulation in vitro–is envisaged to …
to emulate the biology of human tissues, organs and circulation in vitro–is envisaged to …
Whole-organ tissue engineering: decellularization and recellularization of three-dimensional matrix scaffolds
SF Badylak, D Taylor, K Uygun - Annual review of biomedical …, 2011 - annualreviews.org
The definitive treatment for end-stage organ failure is orthotopic transplantation. However,
the demand for transplantation far exceeds the number of available donor organs. A …
the demand for transplantation far exceeds the number of available donor organs. A …
Liver 'organ on a chip'
The liver plays critical roles in both homeostasis and pathology. It is the major site of drug
metabolism in the body and, as such, a common target for drug-induced toxicity and is …
metabolism in the body and, as such, a common target for drug-induced toxicity and is …
Design of artificial extracellular matrices for tissue engineering
The design of artificial extracellular matrix (ECM) is important in tissue engineering because
artificial ECM regulates cellular behaviors, including proliferation, survival, migration, and …
artificial ECM regulates cellular behaviors, including proliferation, survival, migration, and …
Organs-on-a-chip: a focus on compartmentalized microdevices
Advances in microengineering technologies have enabled a variety of insights into
biomedical sciences that would not have been possible with conventional techniques …
biomedical sciences that would not have been possible with conventional techniques …
'Human-on-a-chip'developments: a translational cutting-edge alternative to systemic safety assessment and efficiency evaluation of substances in laboratory animals …
U Marx, H Walles, S Hoffmann… - Alternatives to …, 2012 - journals.sagepub.com
Various factors, including the phylogenetic distance between laboratory animals and
humans, the discrepancy between current in vitro systems and the human body, and the …
humans, the discrepancy between current in vitro systems and the human body, and the …
Control of oxygen tension recapitulates zone-specific functions in human liver microphysiology systems
FT Lee-Montiel, SM George… - Experimental …, 2017 - journals.sagepub.com
This article describes our next generation human Liver Acinus MicroPhysiology System
(LAMPS). The key demonstration of this study was that Zone 1 and Zone 3 …
(LAMPS). The key demonstration of this study was that Zone 1 and Zone 3 …
[HTML][HTML] Microfluidic devices for cell cultivation and proliferation
Microfluidic technology provides precise, controlled-environment, cost-effective, compact,
integrated, and high-throughput microsystems that are promising substitutes for …
integrated, and high-throughput microsystems that are promising substitutes for …
Fluid shear stress modulation of hepatocyte-like cell function
Freshly isolated human adult hepatocytes are considered to be the gold standard tool for in
vitro studies. However, primary hepatocyte scarcity, cell cycle arrest and the rapid loss of cell …
vitro studies. However, primary hepatocyte scarcity, cell cycle arrest and the rapid loss of cell …