Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with a median survival time
from diagnosis of 2–3 years. Although the pathogenic pathways have not been fully …

Organ fibrosis, the result of exaggerated, persistent, and often irreversible accumulation of
extracellular matrix, complicates numerous diseases in all organs and tissues and has …

Innate lymphoid cells (ILCs) represent a distinct branch of the lymphoid lineage composed
of 3 major subpopulations: ILC1, ILC2, and ILC3. ILCs are mainly described as tissue …

Idiopathic pulmonary fibrosis (IPF) is a fatal lung disorder of unknown etiology characterized
by accumulation of lung fibroblasts and extracellular matrix deposition, ultimately leading to …

Background The role of mast cells accumulating in idiopathic pulmonary fibrosis (IPF) lungs
is unknown. Objectives We investigated the effect of fibrotic extracellular matrix (ECM) on …

Background Fibroblast-to-myofibroblast conversion is a major driver of tissue remodelling in
organ fibrosis. Distinct lineages of fibroblasts support homeostatic tissue niche functions, yet …

Whether changes in internal body environment affect kidney aging remains unclear.
Specifically, it is unknown whether transplanted kidneys from older donors recover from …

FIZZ (found in inflammatory zone) 1, a member of a cysteine-rich secreted protein family, is
highly induced in lung allergic inflammation and bleomycin induced lung fibrosis, and …

Amphiregulin (AREG), an epidermal growth factor receptor ligand, is implicated in tissue
repair and fibrosis, but its cellular source and role in regeneration versus fibrosis remain …

Numerous animal models have demonstrated that caloric restriction (CR) is an excellent tool
to delay aging and increase the quality of life, likely because it counteracts age-induced …