Site‐Specific Phosphorylation of Huntingtin Exon 1 Recombinant Proteins Enabled by the Discovery of Novel Kinases
A Chiki, J Ricci, R Hegde, LA Abriata, A Reif… - …, 2021 - Wiley Online Library
Post‐translational modifications (PTMs) within the first 17 amino acids (Nt17) of exon 1 of the
Huntingtin protein (Httex1) play important roles in modulating its cellular properties and …
Huntingtin protein (Httex1) play important roles in modulating its cellular properties and …
A new chemoenzymatic semisynthetic approach provides novel insight into the role of phosphorylation beyond exon1 of Huntingtin and reveals N-terminal fragment …
R Kolla, P Gopinath, J Ricci, A Reif, I Rostami… - bioRxiv, 2021 - biorxiv.org
Huntington's disease is a neurodegenerative disorder caused by the expansion of a
polyglutamine (poly Q) repeat (> 36Q) in the N-terminal domain of the huntingtin protein …
polyglutamine (poly Q) repeat (> 36Q) in the N-terminal domain of the huntingtin protein …