The neurotransmitter acetylcholine (ACh) can regulate neuronal excitability by acting on the
cys-loop cation-conducting ligand-gated nicotinic ACh receptor (nAChR) channels. These …

The basal forebrain cholinergic complex comprising medial septum, horizontal and vertical
diagonal band of Broca, and nucleus basalis of Meynert provides the mayor cholinergic …

Neuronal nicotinic acetylcholine receptors (nAChRs) are a family of ligand gated ion
channels which are widely distributed in the human brain. Multiple subtypes of these …

This study tests the hypothesis that nicotinic cholinergic receptors, including those sensitive
to the antagonist α-bungarotoxin, are decreased in the hippocampus of schizophrenics. The …

Nicotine and other nicotinic agonists have been found to improve performance on attention
and memory tasks. Clinical studies using nicotine skin patches have demonstrated the …

Alzheimer's disease (AD) is a common neurodegenerative brain disorder that causes
cellular response alterations, such as impaired cholinergic mechanism, amyloid‐beta (Aβ) …

The behavioural and cognitive effects of nicotine in schizophrenia have received much
interest in recent years. The rate of smoking in patients with schizophrenia is estimated to be …

The past decade has witnessed an enormous increase in our knowledge of the variety and
complexity of neuropathological and neurochemical changes in Alzheimer's disease …

Objective: The goal of this report is to examine the potential implications of the high
prevalence of smoking in schizophrenia for our understanding of this illness. Method: A …

We investigated the therapeutic efficacy of the selective M1 muscarinic agonist AF267B in
the 3xTg-AD model of Alzheimer disease. AF267B administration rescued the cognitive …