Mitochondrial health is critically dependent on the ability of mitochondria to undergo
changes in mitochondrial morphology, a process which is regulated by mitochondrial …

Currently, one of the main challenges in human molecular genetics is the interpretation of
rare genetic variants of unknown clinical significance. A conclusive diagnosis is of …

Rewiring of energy metabolism and adaptation of mitochondria are considered to impact on
prostate cancer development and progression. Here, we report on mitochondrial respiration …

Human induced pluripotent stem cells (iPSCs) are a valuable tool for studying the cardiac
developmental process in vitro, and cardiomyocytes derived from iPSCs are a putative cell …

Leber's hereditary optic neuropathy (LHON) is a mitochondrial disease mainly affecting
retinal ganglion cells (RGCs). The pathogenesis of LHON remains ill-characterized due to a …

Optic neuropathies are a major cause of visual impairment due to retinal ganglion cell
(RGC) degeneration. Human induced-pluripotent stem cells (iPSCs) represent a powerful …

Mammalian cells, with the exception of erythrocytes, harbor mitochondria, which are
organelles that provide energy, intermediate metabolites, and additional activities to sustain …

Pluripotent stem cells (PSCs), including embryonic stem cells and induced pluripotent stem
cells, show heterogeneity with respect to their pluripotency, self-renewal ability, and other …

Cybrid technology was used to replace Leber hereditary optic neuropathy (LHON) causing
mitochondrial DNA (mtDNA) mutations from patient-specific fibroblasts with wildtype mtDNA …

Mitochondrial diseases disrupt cellular energy production and are among the most complex
group of inherited genetic disorders. Affecting approximately 1 in 5000 live births, they are …