Endothelial dysfunction in diabetes is aggravated by glycated lipoproteins; novel molecular therapies
Diabetes and its vascular complications affect an increasing number of people. This disease
of epidemic proportion nowadays involves abnormalities of large and small blood vessels …
of epidemic proportion nowadays involves abnormalities of large and small blood vessels …
Defective ATG16L1-mediated removal of IRE1α drives Crohn's disease–like ileitis
M Tschurtschenthaler, TE Adolph, JW Ashcroft… - Journal of Experimental …, 2017 - rupress.org
ATG16L1T300A, a major risk polymorphism in Crohn's disease (CD), causes impaired
autophagy, but it has remained unclear how this predisposes to CD. In this study, we report …
autophagy, but it has remained unclear how this predisposes to CD. In this study, we report …
Dysfunctional high-density lipoproteins have distinct composition, diminished anti-inflammatory potential and discriminate acute coronary syndrome from stable …
There is a stringent need to find means for risk stratification of coronary artery diseases
(CAD) patients. We aimed at identifying alterations of plasma high-density lipoproteins …
(CAD) patients. We aimed at identifying alterations of plasma high-density lipoproteins …
Pullulan derivative with cationic and hydrophobic moieties as an appropriate macromolecule in the synthesis of nanoparticles for drug delivery
A new amphiphilic pullulan derivative (DBAP-PO) was obtained by grafting tertiary butyl
amine and octanoyl groups on the pullulan backbone as cationic and hydrophobic moieties …
amine and octanoyl groups on the pullulan backbone as cationic and hydrophobic moieties …
NR4A1 enhances MKP7 expression to diminish JNK activation induced by ROS or ER-stress in pancreatic β cells for surviving
Z Pu, T Yu, D Liu, C Jin, E Sadiq, X Qiao, X Li… - Cell Death …, 2021 - nature.com
Under adverse conditions, such as sustained or chronic hyperglycemia or hyperlipidemia,
ROS (reactive oxygen species) or/and ER-stress (endoplasmic reticulum stress) will be …
ROS (reactive oxygen species) or/and ER-stress (endoplasmic reticulum stress) will be …
Association of paraoxonase1 enzyme and its genetic single nucleotide polymorphisms with cardio-metabolic and neurodegenerative diseases
H Jeelani, N Tabassum, F Rashid - Gene Reports, 2020 - Elsevier
Abstract Paraoxonase1 (PON1) is an antioxidant enzyme on HDL particle and is associated
with hydrolase, esterase and lactonase activities. It has a potential to hydrolyze diverse …
with hydrolase, esterase and lactonase activities. It has a potential to hydrolyze diverse …
Clusterin, paraoxonase 1, and myeloperoxidase alterations induce high‐density lipoproteins dysfunction and contribute to peripheral artery disease; aggravation by …
Peripheral artery disease (PAD) is an atherosclerotic disorder affecting arteries of the lower
limbs, the major risk factors including dyslipidemia and diabetes mellitus (DM). We aimed to …
limbs, the major risk factors including dyslipidemia and diabetes mellitus (DM). We aimed to …
Zingiber officinale extract administration diminishes steroyl-CoA desaturase gene expression and activity in hyperlipidemic hamster liver by reducing the oxidative and …
Abstract Background Stearoyl CoA desaturases (SCD) are enzymes that convert saturated
to monounsaturated fatty acids and have increased activity in hepatic steatosis. Purpose We …
to monounsaturated fatty acids and have increased activity in hepatic steatosis. Purpose We …
Regulation of microRNAs in high-fat diet induced hyperlipidemic hamsters
T Barbalata, L Zhang, MD Dulceanu, CS Stancu… - Scientific Reports, 2020 - nature.com
Dyslipidemia is a documented risk factor for cardiovascular diseases and other metabolic
disorders. Therefore, the analysis of hyperlipidemia (HL)-related miRNAs is a potential …
disorders. Therefore, the analysis of hyperlipidemia (HL)-related miRNAs is a potential …
Inhibition of miR-486 and miR-92a decreases liver and plasma cholesterol levels by modulating lipid-related genes in hyperlipidemic hamsters
LS Niculescu, N Simionescu, EV Fuior… - Molecular biology …, 2018 - Springer
In the present study we aimed to evaluate the potential of in vivo inhibition of miR-486 and
miR-92a to reverse hyperlipidemia, then to identify and validate their lipid metabolism …
miR-92a to reverse hyperlipidemia, then to identify and validate their lipid metabolism …