Current paradigms of cancer-centric therapeutics are usually not sufficient to eradicate the
malignancy, as the cancer stroma may prompt tumour relapse and therapeutic resistance …

Cancers are not composed merely of cancer cells alone; instead, they are complex
'ecosystems' comprising many different cell types and noncellular factors. The tumour stroma …

The inherent plasticity and resiliency of fibroblasts make this cell type a conventional tool for
basic research. But where do they come from, are all fibroblasts the same, and how do they …

Here, we propose a new model for understanding the Warburg effect in tumor metabolism.
Our hypothesis is that epithelial cancer cells induce the Warburg effect (aerobic glycolysis) …

Much interest is currently focused on the emerging role of tumor-stroma interactions
essential for supporting tumor progression. Carcinoma-associated fibroblasts (CAFs) …

Abstract Background Cancer-associated fibroblasts (CAFs) contribute notably to colorectal
cancer (CRC) tumorigenesis, stiffness, angiogenesis, immunosuppression and metastasis …

Simple Summary Cancer-associated fibroblasts (CAFs) play an important contributory role in
the microenvironment of tumors. They originate from different cells, have multiple pro-and …

Cancer-associated fibroblasts (CAFs) are the most important component of the stromal cell
population in the tumor microenvironment and play an irreplaceable role in oncogenesis …

Tumor microenvironment has emerged as an important target for cancer therapy. In
particular, cancer-associated fibroblasts (CAF) seem to regulate many aspects of …

Accumulating evidence suggests that mesenchymal stem cells (MSCs) are recruited to the
tumor microenvironment; however, controversy exists regarding their role in solid tumors. In …