Turning foes to friends: targeting cancer-associated fibroblasts
X Chen, E Song - Nature reviews Drug discovery, 2019 - nature.com
Current paradigms of cancer-centric therapeutics are usually not sufficient to eradicate the
malignancy, as the cancer stroma may prompt tumour relapse and therapeutic resistance …
malignancy, as the cancer stroma may prompt tumour relapse and therapeutic resistance …
Targeting the tumour stroma to improve cancer therapy
KC Valkenburg, AE De Groot, KJ Pienta - Nature reviews Clinical …, 2018 - nature.com
Cancers are not composed merely of cancer cells alone; instead, they are complex
'ecosystems' comprising many different cell types and noncellular factors. The tumour stroma …
'ecosystems' comprising many different cell types and noncellular factors. The tumour stroma …
Origin and functional heterogeneity of fibroblasts
VS LeBleu, EG Neilson - The FASEB Journal, 2020 - Wiley Online Library
The inherent plasticity and resiliency of fibroblasts make this cell type a conventional tool for
basic research. But where do they come from, are all fibroblasts the same, and how do they …
basic research. But where do they come from, are all fibroblasts the same, and how do they …
The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma
S Pavlides, D Whitaker-Menezes, R Castello-Cros… - Cell cycle, 2009 - Taylor & Francis
Here, we propose a new model for understanding the Warburg effect in tumor metabolism.
Our hypothesis is that epithelial cancer cells induce the Warburg effect (aerobic glycolysis) …
Our hypothesis is that epithelial cancer cells induce the Warburg effect (aerobic glycolysis) …
Autocrine TGF-β and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts
Much interest is currently focused on the emerging role of tumor-stroma interactions
essential for supporting tumor progression. Carcinoma-associated fibroblasts (CAFs) …
essential for supporting tumor progression. Carcinoma-associated fibroblasts (CAFs) …
Integrated single-cell and bulk RNA sequencing analysis identifies a cancer associated fibroblast-related signature for predicting prognosis and therapeutic responses …
H Zheng, H Liu, Y Ge, X Wang - Cancer cell international, 2021 - Springer
Abstract Background Cancer-associated fibroblasts (CAFs) contribute notably to colorectal
cancer (CRC) tumorigenesis, stiffness, angiogenesis, immunosuppression and metastasis …
cancer (CRC) tumorigenesis, stiffness, angiogenesis, immunosuppression and metastasis …
Cancer-associated fibroblasts: understanding their heterogeneity
K Louault, RR Li, YA DeClerck - Cancers, 2020 - mdpi.com
Simple Summary Cancer-associated fibroblasts (CAFs) play an important contributory role in
the microenvironment of tumors. They originate from different cells, have multiple pro-and …
the microenvironment of tumors. They originate from different cells, have multiple pro-and …
Emerging role of cancer-associated fibroblasts-derived exosomes in tumorigenesis
L Peng, D Wang, Y Han, T Huang, X He… - Frontiers in …, 2022 - frontiersin.org
Cancer-associated fibroblasts (CAFs) are the most important component of the stromal cell
population in the tumor microenvironment and play an irreplaceable role in oncogenesis …
population in the tumor microenvironment and play an irreplaceable role in oncogenesis …
Activation of fibroblasts in cancer stroma
K Räsänen, A Vaheri - Experimental cell research, 2010 - Elsevier
Tumor microenvironment has emerged as an important target for cancer therapy. In
particular, cancer-associated fibroblasts (CAF) seem to regulate many aspects of …
particular, cancer-associated fibroblasts (CAF) seem to regulate many aspects of …
Human ovarian carcinoma–associated mesenchymal stem cells regulate cancer stem cells and tumorigenesis via altered BMP production
K McLean, Y Gong, Y Choi, N Deng… - The Journal of …, 2011 - Am Soc Clin Investig
Accumulating evidence suggests that mesenchymal stem cells (MSCs) are recruited to the
tumor microenvironment; however, controversy exists regarding their role in solid tumors. In …
tumor microenvironment; however, controversy exists regarding their role in solid tumors. In …