Significance: Previously, sulfur dioxide (SO2) was recognized as an air pollutant. However, it
is found to be endogenously produced in mammalian tissues. As a new gasotransmitter …

Pulmonary vascular remodeling is the critical structural alteration and pathological feature in
pulmonary hypertension (PH) and involves changes in the intima, media and adventitia …

Cholestatic liver injuries, characterized by regional damage around the bile ductular region,
lack curative therapies and cause considerable mortality. Here we generated a high …

Periostin, identified as a matricellular protein and an ECM protein, plays a central role in non-
neoplastic diseases. Periostin and its variants have been considered to be normally …

Pulmonary hypertension (PH) is a progressive, pulmonary vascular disease with high
morbidity and mortality. Unfortunately, the pathogenesis of PH is complex and remains …

Sulfur hexafluoride (SF 6) is the most potent greenhouse gas contributed by the power and
semiconductor industries. The global emissions of gas in the past 10 years have increased …

Abstract Hypoxia-inducible factors (HIF)-1 and HIF-2 are master regulators of oxygen
homeostasis that regulate the expression of thousands of genes in order to match O2 supply …

Elevated blood pressure caused by excessive salt intake is common and associated with
cardiovascular diseases in most countries. However, the composition and responses of …

BACKGROUND: Pulmonary hypertension, characterized by vascular remodeling, currently
lacks curative therapeutic options. The dysfunction of pulmonary artery endothelial cells …

There is a specific reactivity and characteristic remodeling of the periocular tissue in thyroid-
associated ophthalmopathy (TAO). However, local cell changes responsible for these …