Autophagy is a conserved lysosomal degradation pathway where cellular components are
dynamically degraded and re-processed to maintain physical homeostasis. However, the …

Although molecular targeted therapies have recently displayed therapeutic effects in acute
myeloid leukemia (AML), limited response and acquired resistance remain common …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Initiation is the rate-limiting step in translation, and its dysregulation is vital for
carcinogenesis, including hematopoietic malignancy. Thus, discovery of novel translation …

Epigenetic programs are dysregulated in acute myeloid leukemia (AML) and help enforce
an oncogenic state of differentiation arrest. To identify key epigenetic regulators of AML cell …

Long noncoding RNAs (lncRNAs) are usually 5′ capped and 3′ polyadenylated, similar to
most typical mRNAs. However, recent studies revealed a type of snoRNA-related lncRNA …

In Alzheimer's disease (AD), where amyloid-β (Aβ) and tau deposits in the brain,
hyperexcitation of neuronal networks is an underlying disease mechanism, but its cause …

Purpose: Although chemotherapies kill most cancer cells, stem cell–enriched survivors seed
metastasis, particularly in triple-negative breast cancers (TNBC). TNBCs arise from and are …

Small nucleolar RNAs (snoRNAs) are commonly acknowledged as a class of homogeneous
non-coding RNAs that guide ribosomal RNA modifications. However, snoRNAs referred to …

Lysosomes, since their discovery, have been primarily known for degrading cellular
macromolecules. However, in recent studies, they have begun to emerge as crucial …