Currently, there is no disease-modifying treatment available for Alzheimer's and Parkinson's
disease (AD and PD) and that includes the highly controversial approval of the Aβ-targeting …

Iron dyshomeostasis can cause neuronal damage to iron-sensitive brain regions.
Neurodegeneration with brain iron accumulation reflects a group of disorders caused by iron …

Biologically formed nanoparticles of the strongly magnetic mineral, magnetite, were first
detected in the human brain over 20 y ago [Kirschvink JL, Kobayashi-Kirschvink A …

Cortical iron has been shown to be elevated in Alzheimer's disease (AD), but the impact of
the directly measured iron on the clinical syndrome has not been assessed. We investigated …

As people age, iron deposits in different areas of the brain may impair normal cognitive
function and behavior. Abnormal iron metabolism generates hydroxyl radicals through the …

Disruption of cerebral iron regulation appears to have a role in aging and in the
pathogenesis of various neurodegenerative disorders. Possible unfavorable impacts of iron …

Quantitative susceptibility mapping (QSM) has enabled magnetic resonance imaging (MRI)
of tissue magnetic susceptibility to advance from simple qualitative detection of hypointense …

Airborne particulate matter poses a serious threat to human health. Exposure to nanosized
(< 0.1 μm), vehicle-derived particulates may be hazardous due to their bioreactivity, their …

Abstract See Derry and Kent (doi: 10.1093/awx167) for a scientific commentary on this
article. The large variance in cognitive deterioration in subjects who test positive for amyloid …

Abstract Purpose of Review Accumulating research indicates that ambient outdoor air
pollution impacts the brain and may affect neurodegenerative diseases, yet the potential …