Human papillomavirus (HPV) causes virtually all cervical cancers and many cancers at other
anatomical sites in both men and women. However, only 12 of 448 known HPV types are …

A majority of human papillomavirus (HPV) infections are asymptomatic and self-resolving in
the absence of medical interventions. Various innate and adaptive immune responses, as …

The apolipoprotein B messenger RNA-editing, enzyme-catalytic, polypeptide-like 3
(APOBEC3) family of cytidine deaminases plays an important role in the innate immune …

HPV16 causes half of cervical cancers worldwide; for unknown reasons, most infections
resolve within two years. Here, we analyze the viral genomes of 5,328 HPV16-positive case …

The life cycle of human papillomaviruses (HPV) is tightly regulated by the differentiation
state of mucosal and cutaneous keratinocytes. To counteract viral infection, constitutively …

Abstract Human papillomavirus type 16 (HPV16) is the most common cause of cervical
cancer, but most infections are transient with lesions not progressing to cancer. There is a …

Abstract The APOBEC3 (A3) family plays a pivotal role in the immune system by performing
DNA/RNA single-strand deamination. Cancers mostly arise from the accumulation of chronic …

Recently, a deletion in the human apolipoprotein B mRNA-editing enzyme catalytic
polypeptide-like 3 (APOBEC3) gene cluster has been associated with a modest increased …

The AID/APOBEC enzymes deaminate cytosines in single-stranded DNA (ssDNA) and play
key roles in innate and adaptive immunity. The resulting uracils cause mutations and strand …

With the rise of antiviral and anticancer drug resistance, a new approach must be taken to
overcome this burden. The APOBEC3 (A3) family of cytosine deaminases hypermutate …