Using C. elegans to discover therapeutic compounds for ageing-associated neurodegenerative diseases

X Chen, JW Barclay, RD Burgoyne, A Morgan - Chemistry Central Journal, 2015 - Springer
Age-associated neurodegenerative disorders such as Alzheimer's disease are a major
public health challenge, due to the demographic increase in the proportion of older …

Towards improved screening of toxins for Parkinson's risk

L Shan, HJ Heusinkveld, KC Paul, S Hughes… - npj Parkinson's …, 2023 - nature.com
Parkinson's disease (PD) is a chronic, progressive and disabling neurodegenerative
disorder. The prevalence of PD has risen considerably over the past decades. A growing …

LRRK2 and RAB7L1 coordinately regulate axonal morphology and lysosome integrity in diverse cellular contexts

T Kuwahara, K Inoue, VD D'Agati, T Fujimoto… - Scientific reports, 2016 - nature.com
Leucine-rich repeat kinase 2 (LRRK2) has been linked to several clinical disorders including
Parkinson's disease (PD), Crohn's disease and leprosy. Furthermore in rodents, LRRK2 …

Chronic exposure to a glyphosate-containing pesticide leads to mitochondrial dysfunction and increased reactive oxygen species production in Caenorhabditis …

DC Bailey, CE Todt, SL Burchfield, AS Pressley… - Environmental …, 2018 - Elsevier
Glyphosate-containing herbicides are among the most widely-used in the world. Although
glyphosate itself is relatively non-toxic, growing evidence suggests that commercial …

TDP-43 promotes tau accumulation and selective neurotoxicity in bigenic Caenorhabditis elegans

CS Latimer, JG Stair, JC Hincks… - Disease Models & …, 2022 - journals.biologists.com
Although amyloid β (Aβ) and tau aggregates define the neuropathology of Alzheimer's
disease (AD), TDP-43 has recently emerged as a co-morbid pathology in more than half of …

Advances in ex vivo models and lab-on-a-chip devices for neural tissue engineering

S Mobini, YH Song, MW McCrary, CE Schmidt - Biomaterials, 2019 - Elsevier
The technologies related to ex vivo models and lab-on-a-chip devices for studying the
regeneration of brain, spinal cord, and peripheral nerve tissues are essential tools for neural …

Exendin-4 alleviates β-Amyloid peptide toxicity via DAF-16 in a Caenorhabditis elegans model of Alzheimer's disease

X Song, Y Sun, Z Wang, Y Su, Y Wang… - Frontiers in aging …, 2022 - frontiersin.org
Epidemiological analyses indicate that type 2 diabetes mellitus (T2DM) is a risk factor for
Alzheimer's disease (AD). They share common pathophysiological mechanisms. Thus, it has …

Using a Caenorhabditis elegans Parkinson's Disease Model to Assess Disease Progression and Therapy Efficiency

S Hughes, M van Dop, N Kolsters, D van de Klashorst… - Pharmaceuticals, 2022 - mdpi.com
Despite Parkinson's Disease (PD) being the second most common neurodegenerative
disease, treatment options are limited. Consequently, there is an urgent need to identify and …

Drug screening and drug repositioning as promising therapeutic approaches for spinal muscular atrophy treatment

G Menduti, DM Rasà, S Stanga, M Boido - Frontiers in pharmacology, 2020 - frontiersin.org
Spinal muscular atrophy (SMA) is the most common genetic disease affecting infants and
young adults. Due to mutation/deletion of the survival motor neuron (SMN) gene, SMA is …

Activity of translation regulator eukaryotic elongation factor-2 kinase is increased in Parkinson disease brain and its inhibition reduces alpha synuclein toxicity

A Jan, B Jansonius, A Delaidelli, F Bhanshali… - Acta neuropathologica …, 2018 - Springer
Parkinson disease (PD) is the second most common neurodegenerative disorder and the
leading neurodegenerative cause of motor disability. Pathologic accumulation of …