Using C. elegans to discover therapeutic compounds for ageing-associated neurodegenerative diseases
Age-associated neurodegenerative disorders such as Alzheimer's disease are a major
public health challenge, due to the demographic increase in the proportion of older …
public health challenge, due to the demographic increase in the proportion of older …
Towards improved screening of toxins for Parkinson's risk
Parkinson's disease (PD) is a chronic, progressive and disabling neurodegenerative
disorder. The prevalence of PD has risen considerably over the past decades. A growing …
disorder. The prevalence of PD has risen considerably over the past decades. A growing …
LRRK2 and RAB7L1 coordinately regulate axonal morphology and lysosome integrity in diverse cellular contexts
T Kuwahara, K Inoue, VD D'Agati, T Fujimoto… - Scientific reports, 2016 - nature.com
Leucine-rich repeat kinase 2 (LRRK2) has been linked to several clinical disorders including
Parkinson's disease (PD), Crohn's disease and leprosy. Furthermore in rodents, LRRK2 …
Parkinson's disease (PD), Crohn's disease and leprosy. Furthermore in rodents, LRRK2 …
Chronic exposure to a glyphosate-containing pesticide leads to mitochondrial dysfunction and increased reactive oxygen species production in Caenorhabditis …
DC Bailey, CE Todt, SL Burchfield, AS Pressley… - Environmental …, 2018 - Elsevier
Glyphosate-containing herbicides are among the most widely-used in the world. Although
glyphosate itself is relatively non-toxic, growing evidence suggests that commercial …
glyphosate itself is relatively non-toxic, growing evidence suggests that commercial …
TDP-43 promotes tau accumulation and selective neurotoxicity in bigenic Caenorhabditis elegans
CS Latimer, JG Stair, JC Hincks… - Disease Models & …, 2022 - journals.biologists.com
Although amyloid β (Aβ) and tau aggregates define the neuropathology of Alzheimer's
disease (AD), TDP-43 has recently emerged as a co-morbid pathology in more than half of …
disease (AD), TDP-43 has recently emerged as a co-morbid pathology in more than half of …
Advances in ex vivo models and lab-on-a-chip devices for neural tissue engineering
The technologies related to ex vivo models and lab-on-a-chip devices for studying the
regeneration of brain, spinal cord, and peripheral nerve tissues are essential tools for neural …
regeneration of brain, spinal cord, and peripheral nerve tissues are essential tools for neural …
Exendin-4 alleviates β-Amyloid peptide toxicity via DAF-16 in a Caenorhabditis elegans model of Alzheimer's disease
X Song, Y Sun, Z Wang, Y Su, Y Wang… - Frontiers in aging …, 2022 - frontiersin.org
Epidemiological analyses indicate that type 2 diabetes mellitus (T2DM) is a risk factor for
Alzheimer's disease (AD). They share common pathophysiological mechanisms. Thus, it has …
Alzheimer's disease (AD). They share common pathophysiological mechanisms. Thus, it has …
Using a Caenorhabditis elegans Parkinson's Disease Model to Assess Disease Progression and Therapy Efficiency
S Hughes, M van Dop, N Kolsters, D van de Klashorst… - Pharmaceuticals, 2022 - mdpi.com
Despite Parkinson's Disease (PD) being the second most common neurodegenerative
disease, treatment options are limited. Consequently, there is an urgent need to identify and …
disease, treatment options are limited. Consequently, there is an urgent need to identify and …
Drug screening and drug repositioning as promising therapeutic approaches for spinal muscular atrophy treatment
Spinal muscular atrophy (SMA) is the most common genetic disease affecting infants and
young adults. Due to mutation/deletion of the survival motor neuron (SMN) gene, SMA is …
young adults. Due to mutation/deletion of the survival motor neuron (SMN) gene, SMA is …
Activity of translation regulator eukaryotic elongation factor-2 kinase is increased in Parkinson disease brain and its inhibition reduces alpha synuclein toxicity
A Jan, B Jansonius, A Delaidelli, F Bhanshali… - Acta neuropathologica …, 2018 - Springer
Parkinson disease (PD) is the second most common neurodegenerative disorder and the
leading neurodegenerative cause of motor disability. Pathologic accumulation of …
leading neurodegenerative cause of motor disability. Pathologic accumulation of …